A 3-year position as Postdoctoral Fellow is available at the Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital. The candidate will be associated with the Translational Genomics project group and is financed by the Norwegian Cancer Society through the project “Tracking the evolution of gastrointestinal stromal tumours”. The research will focus upon developing and utilizing computational approaches for the analysis of diverse genomic datasets to investigate the molecular evolution of gastrointestinal stromal tumours, as well as to study the novel mechanisms of resistance to targeted therapies. In order to strengthen our cancer bioinformatics competence, we seek an experienced colleague in advanced bioinformatics.
The Translational Genomics project group is led by Dr. Leonardo A. Meza-Zepeda. The group has for many years investigated the biology and genomics of soft tissue and bone tumours, from single gene to genome-wide studies. Our group utilizes genomic, computational, and molecular approaches in animal models and clinical cohorts to answer fundamental questions concerning patient stratification, cancer disease monitoring and evolution, as well as aspects of drug resistance. The group is immersed in the leading cancer research environment in Norway and works closely with the Genomics and Bioinformatics Core Facilities at Oslo University Hospital.
The successful applicant will participate in integrative analysis of genomics data from projects in the areas of tumour evolution using liquid biopsies, biomarker discovery and drug resistance using single cell transcriptome analysis. The tasks will include
Establishment of bioinformatics pipelines for genomic analysis of somatic mutation detection in tumour and cell-free DNA
Integrative analysis of genomics and transcriptomic data
Establishment of bioinformatics pipelines for single-cell transcriptomic analysis
Participate in writing of scientific publications and grants for research funding
Develop own lines of research within the scope of the project
Previous experience with relevant methods and research within the research field will be considered an advantage.
Completed a PhD or other corresponding education equivalent to a Norwegian doctoral degree in bioinformatics/molecular biology/genomics
Highly motivated candidate with a strong interest in scientific research
Bioinformatics experience in short read DNA sequencing analysis and genome scale integrative analysis of diverse experimental datasets (e.g. whole genome/exome, transcriptomes, and single cell analysis)
Demonstrable skills in programming, biostatistics, and database languages (e.g. Python, Perl, R) and the Linux environment are essential
Candidates with a background in mathematics, computer science and statistics and who have an interest in genome biology are welcome to apply
Familiarity with molecular biological techniques involved in genomics experiments is advantageous
Excellent English written and verbal communication skills
The candidate should be able to work independently as well as part of a multidisciplinary team
Good communication skills are required as the successful applicant is expected to interact closely with experimental colleagues
A position as Post-doctoral research fellow (temporary employment for up to 3 years)
Rigorous research training and supervision
Favourable pension arrangement