Postdoctoral Research Scientist
Mitochondrial DNA mutations and cancer
Dr Payam Gammage
Starting Salary from £31,604 to £41,929 (Depending on experience) plus relocation allowance where appropriate. Initial 3 year fixed term contract.
Would you like to develop your scientific career in a research institute that is founded on the quality of its people, acknowledged for its collaborative environment and designed to promote the development of the most outstanding and dedicated scientists. Many early career researchers have already made that decision and at present over 100 of them are now benefiting from our excellent training programme.
The Cancer Research UK Beatson Institute supports cutting edge research into the molecular mechanisms of cancer development and is one of the leading research institutes in Europe. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies, with special emphasis on imaging, metabolomics, and in vivo models.
Our innovative and ambitious research themes focus on understanding the regulation of the tumour microenvironment and cancer metabolism, in particular:
• Intrinsic cancer cell vulnerabilities caused by cell growth
• Interplay between the tumour microenvironment, metastasis and recurrence
• Biology of early disease, aimed at developing a ‘Precision Prevention’ approach
We currently have a vacancy for a Postdoctoral Scientist to explore the role of metabolic dysfunction in cancer. Metabolic dysfunction is intimately linked with cancer initiation and progression and rewiring of mitochondrial metabolism can greatly benefit the cancer cell, fuelling proliferative and invasive cellular behaviours (Gaude et al., 2018).
Mutations of the mitochondrial genome are the most common source of inherited metabolic disease in humans, and that mtDNA mutations cause mitochondrial dysfunction is clear (Gammage et al., 2018a). However the contribution of mutated mtDNA in cancer remains to be addressed.
To better understand the nature of metabolic dysfunction in cancer, through use and development of novel genetic tools (Gammage et al., 2018b) in cellular and animal models, we aim to further untangle the role of mitochondrial DNA mutations in human cancer (Gaude et al., 2018).
Applicants must have a PhD in a relevant field, be driven by scientific curiosity, and have an excellent publication record in mitochondrial biology and/or cancer biology and metabolism. Experience with in vivo models of cancer and genome engineering techniques will be an advantage.
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of mitochondrial oncogenetics please contact Dr Payam Gammage (email@example.com)
Gammage et al., 2018a, Trends in Genetics. 34:101-110
Gammage et al., 2018b, Nature Medicine. 24:1691-1695
Gaude et al., 2018, Molecular Cell. 69: 581-593.
At the Cancer Research UK Beatson Institute, we are committed to increasing the number of female scientists at this level and strongly encourage female applicants to apply. We have recently introduced a highly attractive, innovative maternity policy, which includes providing a postdoc with support and funding so that their projects can continue during their maternity leave.
All applications must be made via our website at http://www.beatson.gla.ac.uk/careers/postdoctoral-fellows/.
Closing date for applications: Friday 29th March 2019