Mitochondria are organelles that produce cellular energy in the form of ATP. The mitochondrion is a unique organelle since it contains multiple copies of a double-stranded circular DNA genome, mtDNA, that encodes for core components of the energy-producing machinery. Defects in mtDNA maintenance can lead to cellular energy deficiency and manifest as human disease. This project aims to characterize the molecular mechanisms that may activate the DNA damage response when mtDNA levels plummet, and that thus guarantee that mtDNA is maintained at a sufficient level in the eukaryotic cell.
We now offer up to two postdoctoral stipends for 2 years each to study the connection between mitochondrial DNA and the DNA damage checkpoints using a combination of human cell culture experiments, yeast genetics and protein biochemistry. The research will be carried out at the Department of Medical Biochemistry and Biophysics that offers a stimulating and international research environment. The scholarships are full-time for two years.
The candidate should hold, or be about to be awarded, a PhD degree or equivalent in cell or molecular biology, biochemistry, genetics or a related discipline. We are seeking highly motivated applicants with experience in cell culture experiments, yeast genetics and/or the expression and purification of recombinant proteins. Experience in the fields of mitochondrial DNA metabolism or the DNA damage response is a merit. An ability to work independently and as part of a team is required. Good oral and written communication skills in English are essential.
The application be a single pdf document with the following:
• a cover letter describing your scientific background and goals for this post-doctoral period (max. one A4 page),
• a CV with full publication list,
• copies of relevant degree certificate(s),
• names and contact information of three reference persons.
The application is to be sent to firstname.lastname@example.org by March 3rd 2019 at the latest, stating the reference number FS 2.1.6-195-19 in the subject line.
For further information, please see www.umu.se/en/research/groups/paulina-wanrooij/
Information about us
The Department of Medical Biochemistry and Biophysics is located within the Chemical Biological Centre (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the natural sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: https://www.umu.se/en/chemical-biological-centre/.
Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. 4 000 employees and nearly 34 000 students have already chosen Umeå University. We welcome your application!
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