A postdoc scholarship in experimental neuro-oncology is available at the Division of Translational Cancer Research. Projects in the Alexander Pietras lab involve modeling and characterization of phenotypic intratumoral heterogeneity, regulation of brain tumor stem cell phenotypes, mechanisms of therapeutic resistance, and stem cell niche—tumor cell interactions, primarily in high-grade glioma.
Recent selected publications:
Johansson E, Grassi ES, Pantazopoulou V, Tong B, Lindgren D, Berg TJ, Pietras EJ, Axelson H, and Pietras A. CD44 interacts with HIF-2α to modulate the hypoxic phenotype of perinecrotic and perivascular glioma cells. Cell Rep, 2017 20(7): 1641-1653.
Pietras A, Katz AM, Ekström EJ, Wee B, Halliday JJ, Pitter KL, Werbeck JL, Amankulor NM, Huse JT, and Holland EC. Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell, 2014 Mar 6;14(3):357-69.
Tong B*, Pantazopoulou V*, Johansson E, and Pietras A. The p75 neurotrophin receptor enhances HIF-dependent signaling in glioma. Exp Cell Res, 2018 Oct 1;371(1):122-129.
Wee B*, Pietras A*, Ozawa T, Bazzoli E, Podlaha O, Antczak C, Westermark B, Nelander S, Uhrbom L, Forsberg-Nilsson K, Djaballah H, Michor F, and Holland EC. ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells. Sci Rep, 2016 Jul 26;6:25956
Candidates must have a PhD or equivalent degree in a relevant field (ideally cancer or stem cell biology), and experience and expertise in one or more of the following: cell- and molecular biology, in vivo modeling of cancer, bioinformatics. The successful candidate is expected to have first author publication(s) in journals relevant to the field, and strong communication skills in English. Candidates must be highly motivated to pursue postdoctoral studies independently within an international and interactive research group.
Formal requirements for scholarship eligibility:
The applicant should not have been employed by Lund University within the last two years in order to be able to receive a scholarship. PhD degree should not be more than three years old at the last day of applying,
Placement: Division of Translational Cancer Research, Medicon Village, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Lund, Sweden
Duration: 2 years
Starting time: 2019-05-01 or later
Last day for applying: 2019-03-31
Interested candidates may submit their CV along with a cover letter stating their interest in the scholarship. For further information please contact:
Alexander Pietras, PhD