College of Health & Life Sciences
Department of Life Sciences
Division of Biosciences
Institute of Environment, Health and Societies
Postdoctoral Research Fellow in Cell and Gene Therapy
Vacancy Ref: 12840
Salary (Grade): R1: £35,365 – £39,511 per annum including London Allowance
Full-time, Fixed Term – 2 years
Start date: 1 May 2019 or soon after
Applications are invited for a post-doctoral position funded by the Medical Research Council. The position is supported initially for 2 years and is full time. The successful candidate will use a new cell and gene therapy method based on the delivery of tissue-penetrating peptides in a model of the genetic disease Friedreich’s ataxia. Friedreich’s ataxia is a rare monogenic condition affecting the nervous system, muscle and heart for which there is no definitive cure.
The study will be conducted in the Department of Life Sciences at the Uxbridge Campus of Brunel University London. The post holder will be supervised by the Prof Arturo Sala in collaboration with Dr Mark Pook from the Department of Life Sciences, Prof Adrian Thrasher and Dr Giorgia Santilli from the Section of Molecular and Cellular Immunology, UCL Institute of Child Health. The supervisory team will offer the postdoc the opportunity to be part of a research network with an international reputation in genetic diseases. Funds are available for participation in research conferences.
- The project would be ideally suited to a researcher with a PhD or MD/PhD in Pharmacology, Immunology, Genetics, Biochemistry, Cell Biology or similar disciplines.
- Hands on experience in haematopoietic stem cell isolation and gene transfer, molecular cloning, gene targeting, and in vivo models of human diseases is essential.
- Evidence of research attainments including examples of written contributions in academic publications/journals
- Proven experience of planning research, and writing for peer reviewed journals
- Experience in presenting data
- Demonstrate ability in acquiring and Interpreting research data and results
Friedreich’s Ataxia (FA) is caused by mutations in the frataxin gene, which cause reduced expression of the frataxin protein in target tissues. The purpose of this investigation is to verify whether secreted, tissue penetrating forms of frataxin can be delivered by mouse and human haematopoietic stem cells, rescuing the FA phenotype in vitro and in vivo.
How to apply
Please include with your application;
An up to date CV and a single page A4, single spaced cover letter setting out why you are a suitable candidate. Please state the name of the project at the top of the page.
Informal enquires may be addressed to Professor Arturo Sala, e-mail: email@example.com
Closing date for applications: Sunday 24 February 2019
For further details and to apply please visit https://careers.brunel.ac.uk