Postdoctoral Research Associate in Single Molecule Trapping and Measurement in Solution

Physical and Theoretical Chemistry Laboratory, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: £32,236 - £39,609 p.a.

Professor Madhavi Krishnan's laboratory is looking for a talented and highly motivated Postdoctoral Research Associate with a strong background in physics, biophysics, or physical chemistry, to join them on a research project funded by EC for a period of one year with possible extension. The project is focused in taking forward an exciting emerging area of microscopy-based single molecule measurement.

The group works in the broad area of soft condensed matter at the nanometer scale and has a specific interest in measuring and understanding electrostatics in molecular-scale matter, e.g., biological macromolecules. Using the repulsive electrostatic interaction in solution, the group recently demonstrated the ability to spatially trap single molecules in solution without the use of external forces (Nature, 2010; Nature Nanotechnology, 2012; Nature Nanotechnology, 2017). This “field-free” trap now enables measurements of the physical properties of macromolecules such as their electrical charge, size and 3D conformation with unprecedented precision, one at a time and in real time. The experimental approaches involved centre around optical imaging and spectroscopy and nanofabrication techniques. The work also relies on theory and simulation, specifically focusing on numerical mean-field electrostatics calculations and Brownian Dynamics simulations. Find out more about the research group at

Duties will include managing own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines and testing hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.

The ideal candidate will hold a PhD in physics, physical chemistry, biophysics, or a related area, or have submitted a PhD thesis prior to taking up the appointment.

Candidates with a strong background in single-molecule fluorescence and optical microscopy are strongly encouraged to apply.

In order to apply for this position, please apply online and submit a single PDF consisting of a cover letter (explaining your background and motivation), CV including contact information for your references, and publication record.

The postholder will be based in the Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA.

Only applications received before 12.00 midday on 6 March 2019 can be considered.

The University of Oxford and the Department of Chemistry are Athena SWAN Silver award holders. Applications are particularly welcome from women and black and ethnic minority candidates, who are under-represented in Chemistry research posts in Oxford.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-139207