Postdoctoral Researcher

Nuffield Department of Clinical Neurosciences, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 7: £32,236 - £39,609 p.a.

Please note that there are two positions available in this project. Should you wish to be considered for both, please ensure that you also submit an application for the following vacancy: 138963.

We are looking for talented, ambitious and dedicated scientists to work on a new project to understand the blood-brain-barrier in health and disease.

You will be part of the IM2PACT consortium, an important multi-centre European project led by Dr Zameel Cader. The aims of the project are to profile the molecular changes in the human blood-brain-barrier using bulk and single cell transcriptomics and proteomics. This will then inform the development of human induced pluripotent stem cell based disease models of neurovascular units.

You will be developing advanced stem cell disease models of the blood-brain-barrier. You will need to demonstrate extensive experience with human embryonic or induced pluripotent stem cells and differentiation methods. You will be required to provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, and PhD and project students.

To be considered for this post, you must hold a relevant PhD/DPhil and have excellent tissue culture skills, specifically with induced pluripotent stems cells or embryonic stem cells. You should possess molecular biology skills including PCR, gRT-PCR, Western Blotting, Immunofluorescence, plasmid transfection or viral transduction. Previous use of stem cell disease models to understand mechanisms of neurological, vascular or cerebrovascular disorders would prove advantageous.

You are encouraged to contact Dr Zameel Cader (, to discuss the project further.

The post is full-time for a fixed-term until 31 March 2022 in the first instance.

Only applications received before 12.00 midday on 4 March 2019 will be considered. Interviews will be held on 14 March 2019.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-138962