Research Technician

Research Technician

Howard Hughes Medical Institute (HHMI)

Boston, MA, United States

Job Description

Howard Hughes Medical Institute (HHMI) is a science philanthropy whose mission is to advance biomedical research and science education for the benefit of humanity.  We empower exceptional scientists and students to pursue fundamental questions about living systems, and work to share scientific discoveries with researchers, students, and science-curious individuals around the world.


Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2500 people across the U.S.  Visit to learn more about working at HHMI.


The Pellman Laboratory ( at the Howard Hughes Medical Institute and the Dana-Farber Cancer Institute in Boston is seeking a highly motivated Research Technician to assist in a laboratory studying cell division and cancer biology. The laboratory uses a combination of genetics, biochemistry, and live-cell imaging to study cell division and the maintenance of genome stability. Projects are aimed at defining how cell division errors impact genome rearrangements. A recent focus is understanding how genome rearrangements occur in cancer, using pancreatic cancer organoids as a model system.

Under general supervision, the Research Technician will perform a variety of laboratory and investigative procedures including routine experimental techniques such as electrophoresis, centrifugation, Western blot, real-time quantitative PCR, molecular cloning, and tissue culture. For projects using organoids derived from mouse models, prior mouse handling experience is encouraged. Technicians will need to collect, verify, record, and compile data and information in support of research. Technicians commonly have the opportunity to present at lab meetings, contribute to manuscripts, and attend national conferences. Approximately 80% of time worked will be dedicated to research, with remaining time spent ordering supplies and performing other lab management responsibilities. Many former technicians from the laboratory have been accepted to top Ph.D., M.D./Ph.D. or M.D. programs. Several former technicians are now independent investigators. Technicians typically work with a postdoctoral fellow; however, a few technicians have had independent projects.


Principal Responsibilities:

  • Work with postdoctoral scientists to perform various investigative procedures and operate a variety of instruments and other scientific equipment.
  • Collect, record, organize, and verify the accuracy of data; perform calculations and prepare charts, graphs and reports. May use software applications to assemble, manipulate and/or format data and test reports.
  • Configure, operate and maintain laboratory apparatus and instruments; read and record instrument data; tabulate data; keep laboratory records.
  • Order chemicals, reagents, and other laboratory supplies.
  • Participate in laboratory meetings and planning sessions.
  • Responsible for lab organization and orders.
  • Keep accurate record of all work.
  • Maintain strains and cell lines.
  • Serve as laboratory safety and radiation safety representative.
  • Read literature applicable to research areas as required.
  • Inquisitive thinker who will impact the scope and direction of research projects.


Preferred Qualifications:

  • Bachelor or Master of Science degree in an appropriate field of science or technology.
  • Prior laboratory experience.
  • Molecular Biology skills are required. Experience with microscopy and tissue culture would be beneficial.
  • Ability to draft routine reports and keep accurate records of work performed.
  • Actively seeks opportunities to increase skills and expertise.
  • Able to learn complex tasks with general instruction.
  • Able to learn and perform a variety of new techniques.


Additional Information: Please include a cover letter and three references with your resume.


HHMI is an EOE

Required Skills

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Please apply via recruiter’s website.

Quote Reference: Howard Hughes Medical Institute (HHMI)-hhmi-Pellman 088104