Postdoctoral Position - Molecular Mechanisms of 3D Chromatin Loop Formation (f/m/d)

Helmholtz-Center München - German Research Center for Environmental Health (HMGU) - HMGU - Helmholtz Association

Munich, Bavaria, Germany

Work group:

Helmholtz Pioneer Campus

Area of research:

PHD Thesis

Starting date:


Contract time limit:


Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

The Helmholtz Pioneer Campus (HPC) is an innovation campus with a startup culture at the Helmholtz Zentrum München. HPC stands for the smart fusion of biomedical sciences, engineering and digitization in a research environment that has no parallel in Europe.

The 3D Genome and Molecular Neuroscience group headed by Dr Boyan Bonev is looking for a highly motivated postdoctoral fellow interested in studying how chromatin interactions between regulatory regions in the genome are established, maintained and reset during development. The project will utilize cutting-edge technologies such as mass spectrometry, genome engineering and live imaging in order to address one of the fundamental questions in chromatin biology.

Postdoctoral Position - Molecular Mechanisms of 3D Chromatin Loop Formation (f/m/d)

The challenge

The Bonev lab studies how 3D genome organization and epigenetic modifications regulate cell identity during brain development. Using highly interdisciplinary approaches such as single cell multi-omics, live imaging and computational biology, we aim to understand how chromatin landscape influences cell fate decisions in development and evolution. We are based at the Helmholtz Zentrum München and hence part of an excellent network dedicated to epigenetics and neurosciences including the MPI for Neurobiology, the LMU and TU Munich as well as broad international collaborations.

We have previously discovered that regulating 3D chromatin architecture and enhancer-promoter interactions plays an important role in the control of gene expression and cell fate (Bonev et al., Cell 2017). Using ultrahigh resolution Hi-C we have uncovered thousands of cell-type specific regulatory contacts, which are usually not associated with canonical architectural proteins such as CTCF. How such dynamic chromatin loops are established and maintained and what is their role during development and disease is largely unknown. The goal of this exciting research project is to uncover the molecular mechanisms behind cis-regulatory loop formation, study how cell-type specific 3D regulatory loops are regulated during development and what are the consequences for gene expression.

Your profile

Our ambitious and interdisciplinary team consists of passionate and motivated people from around the world. To further support our research, we are looking for talents willing to develop and execute the next breakthrough ideas. Ideal candidates therefore require:

PhD in the life sciences or related disciplines Good publication record with evidence of independence (at least one first-author publication in an international journal)Strong background in molecular cell biology, especially chromatin biologyExperience with mammalian cell culture and NGS technologies (preferred)Fluent in written and spoken English

What we offer

In order to promote your professional development, we offer a dynamic working environment, advanced training in molecular biology and genetics, and cutting-edge NGS and single cell technologies. You will interact and benefit from our collaborative approach to research and the presence of senior groups in the immediate proximity. Furthermore, we will provide you with training in grant and manuscript writing, funding for relevant courses and workshops, support with fellowship applications and a detailed career development plan.

Remuneration and benefits are in accordance with the collective agreement for the public sector (TV EntgO Bund). The position is initially limited to two years with the option of extension. The Helmholtz Zentrum München is an equal opportunity employer and embraces diversity. We are located in a city with a vibrant cultural and social life, consistently selected to be in the top 5 global cities to live in. We offer a family friendly environment, flexible working hours, a child care facility on Campus and dual career opportunities. We are a certified holder of the Total E-Quality Award. In order to increase the proportion of women in management positions, we are pleased to receive corresponding applications. Qualified applicants with physical disabilities will also be given preference.

We are looking forward to receiving your online application (motivation letter, CV, contact details of at least 2 referees and a brief description of research interests and future plans) in a single pdf file until February 28, 2019.

Curious? We encourage your inquiries directly to Dr. Boyan Bonev.

Please apply via recruiter’s website.

Quote Reference: Helmholtz-2019/0011