Post-doc on 'Characterization of Heritable Triggers of Prostate Cancer Molecular Subtypes'

Post-doc on 'Characterization of Heritable Triggers of Prostate Cancer Molecular Subtypes'

Demichelis Lab at the CIBIO Department/ University of Trento

Povo, Trento, Italy

The Demichelis laboratory in Computational and Functional Oncology is seeking 1 self-motivated individual with a strong background in molecular and translational cancer biology to join a multidisciplinary research team focused on GU cancers. The laboratory is currently seeking an experimental Post-doc Fellow to lead an AIRC (http://www.airc.it/) funded project, Towards Characterizing Heritable Triggers of Prostate Cancer Molecular Subtypes. The project studies the impact of inherited polymorphisms within transcriptionally active regulatory regions of the genome on the initiation of hormone regulated cancer phenotypes. The project builds on recent published data from the group (PMID: 28663546).

A Postdoctoral Fellow is sought to focus on mechanisms of gene regulation during prostate cancer genesis and downstream effects. The fellow is expected to develop both inter- and intra-laboratory collaborations, and present/publish the results in high impact scientific conferences/journals.

Qualifications:
• Ph.D. in cancer biology or related discipline
• Experience with cancer cell lines
• Excellent oral and written communication skills
• Experience in one or more of the following fields: cancer biology, genetics, epigenetics, molecular biology
• Experience in hormone regulated cancers (e.g. prostate, breast, ovarian)
• Experience in the following techniques is preferred: ChIP, IP, MassSpec, assessment of DNA damage repair impairment and response, Hi-C.

To apply, please submit a single PDF containing CV, two representative publications, a statement of research interest, and contact information for three references to Francesca Demichelis (f.demichelis@unitn.it) and Paola Gasperini (paola.gasperini@unitn.it) Application deadline extended to March 31, 2019.

The Demichelis laboratory
The Computational and Functional Oncology laboratory is dedicated to the study of tumor evolution and the identification of biomarkers of progression and treatment response. Ongoing studies interlace individual’s genetics and tumor molecular characteristics to understand key drivers relevant to precision medicine. Team members should expect to interact seamlessly with national and international laboratory, clinical, and computational focused researchers. Dr. Francesca Demichelis is Professor at the University of Trento, Italy, and is standing member of the Englander Institute for Precision Medicine at Weill Cornell Medicine, NY. She is funded by the European Research Council, the NCI, and cancer research foundations including CR-UK, AIRC, and the Prostate Cancer Foundation. Website: http://demichelislab.eu/

The University of Trento and the CIBIO Department
The University of Trento (https://www.unitn.it/) ranks first among Italian State universities and recently confirmed the quality of research in four academic disciplines: physics, biology, psychology, political and social sciences (data from The Italian National Agency for the Evaluation of Universities and Research Institutes). The CIBIO Department (https://www.cibio.unitn.it/) was founded in 2008. It includes 35 research groups. CIBIO’s infrastructure provides cutting-edge core facilities for internal and external academic research institutions as well as private corporations. They include state-of-the-art next generation sequencing, flow cytometry, advanced imaging, high throughput screening, proteomics, animal modelling, cell technology and bioinformatics services. Notably, this is a unique asset for Italian academic centres that translates in outstanding scientific achievements as certified by CIBIO’s productivity.

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Post-doc on 'Characterization of Heritable Triggers of Prostate Cancer Molecular Subtypes'