Project Title: Immunopathogenesis of in utero Zika virus infection
Institution: VIDO-InterVac, University of Saskatchewan
120 Veterinary Road, Saskatoon, SK S7N 5E3
Start Date: The position is available immediately
Organization: VIDO-InterVac is a preeminent research institute with its primary focus on microbial pathogenesis, vaccine development, and mitigation strategies against both human and animal pathogens. VIDO-InterVac currently has over 150 personnel and state-of-the-art facilities including the International Vaccine Centre (InterVac), one of the most advanced containment level 3 facilities in the world consisting of both laboratories and animal isolation suites.
Project Description: Recent studies in mice and our research in the porcine model demonstrated agitated type I interferon responses in fetuses and fetal environment during in utero Zika virus (ZIKV) infection. The goal of the project is to understand the mechanisms of fetal/fetal environmental interferon alpha (IFN-α) responses to infection and how these responses affect fetal development and health in offspring. The candidate will study the cellular and molecular mechanisms of IFN-α pathology in the fetal pig model for ZIKV infection. The second aim of the project is to develop a humanized pig model. The candidate will study the fate of human stem cells from healthy tissues and tumors after transplantation in fetal brains.
Financial Support: The project is fully funded for two years.
Research Advisor: Uladzimir Karniychuk, DVM, Ph.D. For more information, visit:
Candidate Profile: Candidates must hold a Ph.D. in virology, molecular biology, or another appropriate discipline. Recent Ph.D. graduates are particularly encouraged to apply. Well-developed oral and written communication skills are essential. An ideal candidate will have a strong background in classical and molecular virology techniques, immunohistochemistry, flow cytometry, and western blot. Experience with CRISPR-Cas9 genome editing technology and next-generation sequencing would be an advantage. Experience working with animals is not essential.
The candidate must be highly motivated, creative, and diligent. The successful candidate will be required to undergo and clear a reliability status screening assessment, background check and a criminal record check as a condition of employment.
How to Apply: Email One single application document (pdf file) that includes 1) a letter of motivation, 2) a complete curriculum vitae (CV), 3) contact information for individuals willing to provide a reference for the candidate, to firstname.lastname@example.org
VIDO-InterVac and the University of Saskatchewan is strongly committed to a diverse and inclusive workplace. As such, applications from those who will contribute to the diversity of our community are welcome and all qualified candidates are encouraged to apply. However, Canadian citizens and permanent residents will be given priority.
Only candidates selected for interviews will be contacted