Senior Bioinformatician / Developer (Genome Annotation)

Senior Bioinformatician / Developer (Genome Annotation)

Earlham Institute

Norwich, United Kingdom

Senior Bioinformatician / Developer (Genome Annotation)

Applications are invited for a Senior Bioinformatician/Developer to join the Core Bioinformatics Group at the Earlham Institute (EI).

The role:

This post will focus on developing novel tools and pipelines for large scale annotation of genes and other genomic features across a diverse range of species including plants, mammals and fish.

This role will have responsibility for leading key large-scale annotation projects and continuing to develop and run EI’s annotation pipeline. A key focus will be improving and standardising gene structure annotation to support eukaryotic pan-genome analyses. The successful candidate will be involved in collaborations with biologists and computational scientists from the UK and international institutions.

Furthermore, the role will develop scalable and robust methods to identify transcript structures and analyze transcriptome complexity in eukaryotic species with large, repeat rich and polyploid genomes. The role will involve working with data from cutting edge sequencing technologies including PacBio IsoSeq and Nanopore.

As part of the Core Bioinformatics Group you will:

- Produce high-quality, evidence-based genome annotation of protein-coding, lncRNA and pseudogenes
- Develop methods for improving and comparing annotations across related species / accessions, supporting pan-genome analysis
- Develop approaches for integrating data from a variety of sequencing technologies
- Maintain and develop existing pipelines / annotation tools
- Collaborate with UK and international partners on large-scale annotation projects

The ideal candidate:

The successful candidate will possess a PhD or equivalent experience in computational biology, bioinformatics, computer science or a similar subject. They will also have a strong background in large scale data analysis including experience of transcriptomics and genome annotation.

Candidates should possess a high level of skill and demonstrable experience of building tools and pipelines in Python, along with R and Bash scripting. Experience of the snakemake workflow management system is preferable. The ideal candidate will also be highly collaborative and have demonstrable experience of successfully managing their time to deliver analyses and input into multiple projects.

Additional information:

Salary on appointment will be within the range £39,150 to £47,850 per annum depending on qualifications and experience. This is a full time contract for a period of 3 years.

For further information and details of how to apply, please visit our web site or contact the Human Resources team on 01603 450462 or quoting reference 1003512.

We reserve the right to close the vacancy early, should sufficient applications be received.

As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy.

The closing date for applications will be 18th February 2019.

Please apply via recruiter’s website.

Quote Reference: 1003512