Postdoctoral position (3 years) Understanding the Phenotypic Variability of HNF1B: An integrated Epigenetic/Genetic Approach

Postdoctoral position (3 years) Understanding the Phenotypic Variability of HNF1B: An integrated Epigenetic/Genetic Approach

Institut Necker Enfants Malades

Paris, France

We are looking for a resourceful postdoctoral fellow to join us in the study of the function of HNF1B, a bookmarking transcription factor, frequently mutated in patients suffering from diabetes and/or renal developmental dysfunctions.

The group, “Epigenetics and Development Laboratory”, led by Marco Pontoglio, is located at the “Institut Necker Enfants Malades” INEM, Paris, France. The INEM Institute is an international biomedical research center located on the Necker Hospital Campus, (Montparnasse District) Paris France. The center is supported by the French National Institute of Health and Medical Research (INSERM), the French National Center for Scientific Research (CNRS) and the University Paris Descartes. The close interactions between the research labs and the clinical departments represent a major strength creating a highly dynamic environment. The INEM is the hub for cellular and molecular biology at University Paris Descartes, one of the World’s leading universities. The Institute hosts over 100 talented scientists who are working together to promote scientific discoveries in the study of the molecular and cellular mechanisms of human diseases.

The research activities of our laboratory focus on the mechanisms that control gene expression, morphogenesis and differentiation.

Some publications of the laboratory on these subjects:
Fischer E. et al. Nature Genetics 2006 (https://goo.gl/8mXNJc);
Verdeguer F. et al. Nature Medicine 2010 (https://goo.gl/wuj5aW) ;
Massa F. et al. Development 2013 (https://goo.gl/8hGg6a);
Garcia-Gonzalez M. et al. Scientific Reports 2016 (https://goo.gl/a9bBM3);
Lerner J. et al Nucleic Acids research 2016 (https://goo.gl/UFuy6n);
Phelep A. et al 2017 Plos Genetics (https://goo.gl/okGZKn)

The proposed research project is focused on the study of the mechanisms of the variable penetrance of HNF1B deficiencies in patients. The project is based on the development of a novel and specific biosensor, human genetics, epigenetics and Molecular Biology approaches.

Requirements: ability to work and troubleshoot independently. Particularly appreciated is experience with Molecular and Cellular biology, Cell Culture, ChIP-seq and CRISPR/Cas9. The candidate will be a highly motivated individual with excellent communication and organizational skills.

The position is opened from March 2019

Please, send a motivation letter, the names of 2 referees, and a CV to pontogliolab@gmail.com before 12:00 noon February 15th 2019.

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Position

Postdoctoral position (3 years) Understanding the Phenotypic Variability of HNF1B: An integrated Epigenetic/Genetic Approach