Interdisciplinary PhD Position on Transcription Factor Function

Interdisciplinary PhD Position on Transcription Factor Function

Ecole Polytechnique Fédérale de Lausanne (EPFL)

Lausanne, Vaud, Switzerland

The laboratories of David Suter (UPSUTER) and Beat Fierz (LCBM), both situated at the Ecole Polytechnique fédérale de Lausanne (EPFL), are looking for a PhD student to work on a collaborative project at the interface between biochemistry, biophysics, molecular and cell biology.

EPFL is a world-leading engineering school situated at the shore of Lake Geneva in Switzerland, and fosters interdisciplinarity across basic and engineering science. The Suter and the Fierz lab are tackling fundamental questions in gene expression regulation, using in vivo (Suter lab) and in vitro (Fierz lab) approaches. The aim of this project is to dissect the molecular mechanisms of compact chromatin invasion and mitotic chromosome binding by transcription factors (TFs). This interdisciplinary project will involve a broad range of techniques such as in vitro single-molecule biophysics, CRISPR-Cas9 genome engineering of stem cells, and live imaging of transcription.

If you have a background in biophysics, molecular- or cell biology or related fields and are interested, send a cover letter, CV and the contact information of 3 referees to david.suter@epfl.ch or beat.fierz@epfl.ch. The applications will be evaluated as soon as they are received.

For more information please visit http://suter-lab.epfl.ch/ and https://lcbm.epfl.ch/ or contact us using the email addresses given above.

Key references:

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.
Deluz C, Friman ET, Strebinger D, Benke A, Raccaud M, Callegari A, Leleu M, Manley S, Suter DM.
Genes and Development 2016

Raccaud M, Alber AB, Friman ET, Agarwal H, Deluz C, Kuhn T, Gebhardt JCM, Suter DM.
Mitotic chromosome binding predicts transcription factor properties in interphase.
bioRxiv 2018

Kilic, S., Felekyan S., Doroshenko O., Boichenko I., Dimura M., Vardanyan H, Bryan LC., Arya G, Seidel, CAM & Fierz B., Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α, Nature Commun., 2018, 9(1):235.

Kilic S, Bachmann AL, Bryan LC, Fierz B., Multivalency governs HP1α association dynamics with the silent chromatin state, Nature Commun., 2015, 6, 7313

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Interdisciplinary PhD Position on Transcription Factor Function