Postdoctoral researcher in iPSC Disease Modelling, Metabolomics and Chemical Biology

Postdoctoral researcher in iPSC Disease Modelling, Metabolomics and Chemical Biology

University of Luxembourg

Luxembourg, Luxembourg

The University of Luxembourg is a multilingual, international research University. Luxembourg is a dynamic, multicultural country in the heart of Europe with a strong research and development base supported by important organisational resources.

The Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg offers state-of-the-art facilities and an excellent environment for interdisciplinary research. The Centre is currently looking for a :

Postdoctoral Researcher in iPSC Disease Modelling, Metabolomics, and Chemical Biology (m/f)

  • Ref : 50013181 – (R-AGR-3533-10-C C-C18/BM/12661133 NAXDE
  • Fixed-term contract 2 years, with possibility of prolongation
  • Full-time position (40h/week)
  • Employee status
  • Start date as soon as possible

Your Role

The Enzymology & Metabolism Research Group at the LCSB is looking to hire a postdoctoral researcher to participate in a Translational Biomedical Research project (Cellular and animal models of a new paediatric neurodegenerative disorder to investigate disease mechanism, develop diagnostic tools and test small molecule treatments) funded by the Luxembourg National Research Fund (FNR). We are seeking a highly motivated and talented scientist to investigate the mechanism through which mutations in two metabolite repair genes cause severe neurological impairments in children and to explore therapeutic strategies. The successful applicant will establish and analyse (iPSC-derived) cellular models of the disease, applying Crispr/Cas9 technology and metabolomics as well as imaging-based phenotypic approaches. These models and defined phenotypic readouts will be used to test small molecule therapeutic treatments. Another aim will be to develop enhanced diagnostic tools for the metabolite repair deficiencies.

For further information, please contact:
Dr. Carole Linster (carole.linster@uni.lu)

Your Profile

  • PhD degree in biochemistry, molecular biology, biotechnology or related disciplines, preferably with a focus on cell metabolism
  • Strong theoretical background and practical experience in metabolic biochemistry and molecular as well as cell biology
  • Previous experience with mammalian cell culture, iPSC technology, and mass spectrometry-based metabolomics techniques will be considered as important assets
  • Solid computational and biostatistics skills are required
  • Excellent English writing and speaking skills are essential

We offer

  • Participation in a collaborative project supported by the FNR
  • Opportunity to participate in the development of the well-equipped LCSB metabolomics platfor
  • Project funding available for up to 36 months
  • A dynamic, exciting and equal opportunity international research environment
  • Further Information*
  • Applications (in English) should mention the reference include
  • Cover letter indicating your motivation for this position, relevant past experience and future interest
  • Detailed curriculum vitae, including publications, presentations and/or invited talks
  • Copy of the relevant diplomas
  • Contact details of three referees

Please apply via recruiter’s website.

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