PhD Position on DNA Repair within Chromatin

PhD Position on DNA Repair within Chromatin

Ecole Polytechnique Fédérale de Lausanne (EPFL)

Lausanne, Vaud, Switzerland

Our laboratory of Biophysical Chemistry of Macromolecules (LCBM) at the EPFL in Lausanne, Switzer-land (http://lcbm.epfl.ch/) offers a PhD position for the study of DNA repair processes in chromatin, using a combination of chemical biology methods and single-molecule fluorescence imaging.

Human DNA is exposed to constant damage from external sources (UV light, reactive oxygen species etc.) or internal insults (e.g. replication fork collapse). Rapid, efficient and high-fidelity repair of DNA damage is of crucial importance for human health. DNA damage repair processes are highly complex and involve highly controlled signaling networks between protein factors and combinations of chemical modifications of chromatin.

To reveal the underlying molecular mechanisms, methods outside classical biochemistry are required. Our laboratory has pioneered many novel approaches combining chemical synthesis of defined chromatin fibers and single-molecule imaging methods to observe biology in real time. The aim of this project is thus to develop a novel approach, combining protein and chromatin synthesis and dynamic multiplex single-molecule imaging, to dissect multivalent signaling processes during DNA repair within chromatin.

The ideal candidates for this position have an interest in chemical biology, biophysical chemistry or a related field and have a strong interest in elucidating molecular mechanisms in chromatin regulation.

We are particular looking for candidates with interests in:
- single-molecule methods in biological systems
- protein and peptide chemistry
- quantitative / systems biology and modeling.

EPFL is one of the top research universities in Europe and the world. Situated in the center of Europe at the shore of lake Geneva in Swizerland, EPFL hosts an international body of students, professors and staff from over 125 nations, presents a highly dynamic research environment with a focus on excellence in teaching, research and technology transfer.

The position is open now. To apply for the position, please send a letter of motivation, a CV and the contact information of two referees to Prof. Beat Fierz, beat.fierz@epfl.ch. The applications will be evaluated as they are received.

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PhD Position on DNA Repair within Chromatin