The Chapman laboratory focuses on mechanisms underlying tissue regeneration or progressive fibrosis after major injury to mouse and human lungs. The scope of projects centered on this theme range from basic studies of distal airway stem/progenitor cells responding to alveolar injury to development of small molecules identified through high throughput screens that selectively target fibroblast TGFb1 signaling. See recent publications: Xi et al, NCB 19:904, 2017; Wei et al JCI, October, 2017. Planned projects will involve substantial biochemistry and organoid biology in vitro, in vivo functional assays in injury models, time lapse and high resolution microscopy, and genetically modified mice as reporters and tools for lineage tracing. We benefit from close proximity to UCSF Medical Center where an active transplantation program affords access to normal and diseased human lungs. The goal is to improve lung function after major injury using principles of lung regeneration.
We are particularly interested in recruiting a talented postdoctoral scientist motivated to develop a signaling “toolkit” that converts the mal-adaptive microenvironment of injured lungs into a receptive environment either for endogenous epithelial cell stem/progenitor expansion or for engraftment and improved function after transplantation of exogenous normal stem/progenitors. This project will require improved understanding of the key drivers and regulation of distal airway epithelial stem/progenitor cell mobilization, migration, and differentiation after major lung injury.
There is certainly also opportunity for novel research directions that a new scientist in the lab is motivated to initiate and pursue. We expect the successful candidate to have experience in cell and molecular biology, a genuine interest in repair processes including that of the lung, experience with mouse models, and at least one first author publication. Strong organizational skills, lab notebook practices, and attention to detail are vital. Send CV, summary of research experience and training, and the names and contact details of 3 referees to Hal Chapman (email@example.com).
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.