Postdoctoral Fellow – Immunology / Immunometabolism
The Department of Bioinformatics and Biochemistry (head: Prof. Dr. Karsten Hiller ) dedicates its research to understand the role of metabolism during disease development. We are interested in both, the metabolic adaptations of immune cells during inflammation, and the metabolism of microorganisms during an infection. To determine the metabolic phenotype, we apply and develop analytical and computational technologies centered around mass spectrometry (MS) and stable-isotope labeling.
Our department is located in the Braunschweig Integrated Centre of Systemsbiology (BRICS). BRICS is a joint centre of the Technische Universität and the Helmholtz Center for Infection Research (HZI). BRICS aims to apply interdisciplinary research to investigate molecular mechanisms in infection biology.
The position is part of an international joint project with the Brenner lab from the Luxembourg Institute of Health (LIH). We are interested to investigate the role of reactive oxygen species (ROS) and glutathion in macrophage metabolism based on our previous publication:
Mak, T. W., et al. Glutathione Primes T Cell Metabolism for Inflammation. Immunity 46, 675–689 (2017).
To profile the metabolism of immune cells and their mitochondria, we apply modern technology such as stable-isotope (13C) tracing, mass-spectrometry, metabolic flux analysis, respiration measurements and metabolomics. In addition, our team develops and employs all algorithms and computer programs required for the analysis of high dimensional mass-spectrometric data.
PhD in Immunology, Biochemistry, Molecular Biology or equivalent.
Experience with mammalian immune cells (in vitro primary cells and cell lines).
Proficient in written and spoken English
Strong team player
Temporary contract for three years
Salary according to 100% E13 TV-L
Start date: as soon as possible
Further questions? Interested?
Please apply via email before January 31st to firstname.lastname@example.org
Your application should include a motivation letter explaining your interest and prior research, a CV including publication record and two references.