PhD Student position to study white matter damage in familial Alzheimer's disease

PhD Student position to study white matter damage in familial Alzheimer's disease

Universitatsklinikum Hamburg-Eppendorf

Hamburg, Germany

A three year NIH-funded doctoral position is open at the Institute of Neuropathology, University Medical Center Hamburg – Eppendorf, in Germany, for studies of white matter disease in familial Alzheimer’s disease (AD) and hereditary cerebrovascular disease, under the supervision of Dr. Diego Sepulveda-Falla in close collaboration with Dr. Joseph F. Arboleda-Velasquez from the Schepens Eye Research Institute of Mass Eye and Ear and Harvard Medical School and Dr. Yakeel Quiroz in the Massachusetts Alzheimer’s Disease Research Center community of the Massachusetts General Hospital.

Our research integrates genetic, molecular, neuropathological, clinical and preclinical data to characterize some of the earliest dementia-related brain changes in white matter. The PhD student will have access to two extraordinarily rich preclinical hereditary dementia groups, 1) the Colombian kindred with Presenilin 1 E280A (Glu280Ala) mutation, estimated to have 1,500 mutation carriers; 2) samples and clinical data from individuals with inherited forms of vascular dementia including CADASIL; and, 3) new in vivo models for familial AD and hereditary cerebrovascular disease.

Highly qualified and motivated students are invited to apply. Applicants should have a MSc in neuroscience, cellular biology, or a related discipline. Prior knowledge and experience with in vivo models and vascular biology is desirable.

We offer an open-minded work atmosphere in an interdisciplinary international team collaborating with partners in Europe and the Americas. Hamburg is the second largest city in Germany, with high living quality and a growing scientific community, particularly in structural biology and neurosciences.

The position is open immediately and applications will be accepted until the position is filled. A CV, letter of interest outlining experience and research goals, and contact information of three references should be sent to Diego Sepulveda-Falla (

Employment, payment and social benefits are according to standard guidelines for graduate students in Germany. The University Medical Center Hamburg – Eppendorf is an Equal Opportunity/Affirmative Action Employer.


Apply with CV and Cover Letter

Fields with a * are mandatory
Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

PhD Student position to study white matter damage in familial Alzheimer's disease