Research Associate in Computational Biophysics & Bioinformatics in Virology
University of York, UK
We recently discovered a second code other than the genetic code of human viruses, e.g. in Hepatitis B virus (Patel et al., Nat. Microbiol. 2:17098, 2017) and Parechovirus (Shakeel et al, Nat. Commun. 8:5, 2017) that acts as an instruction manual for virion assembly. This code is written in the form of multiple dispersed RNA sequence/structure motifs in the viral genome, each with affinity for the cognate coat proteins that form the viral protein containers encapsulating the genetic message between rounds of infection. We seek a post-doctoral fellow with programming experience for our Wellcome Trust-funded team in the UK to refine, further develop and apply computational strategies to identify this code in a wide range of RNA viruses based on state-of-the-art experimental data provided by our experimental collaborators based in Leeds. You will also contribute to the exploitation of the assembly code in drug/gene delivery, therapy and vaccination through computational optimization of the assembly code for the design of virus like particles and the identification of its evolutionarily conserved features as potential drug targets. Ability and creativity in developing and implementing computational approaches to interrogate biological systems, and a passion for the exciting biological questions and therapeutic applications are essential for this post.
Candidates should apply via: https://jobs.york.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=3885&p_web_page_id=374694
For informal inquiries, please contact Prof Reidun Twarock Reidun.Twarock@york.ac.uk