Job title: Postdoctoral Training Fellow in Cancer Immunology
Location: The Francis Crick Institute, Midland Road
Contract: Fixed-Term (4 years), Full- time
Salary: Between £33,500 – £36,600 per annum subject to skills and experience
Vacancy ID: 9546
We seek a talented and motivated postdoc in the area of cancer immunology to join Dr. Vivian Li’s laboratory.
Dr Li’s laboratory investigates how Wnt signalling is precisely regulated in intestinal stem cell and cancer, with the emphasis on finding new therapeutic targets. Wnt signalling is altered in nearly all colorectal cancers (CRCs), yet there are significant challenges in targeting the Wnt pathway due to its pivotal role in tissue homeostasis of many body system. Deciphering Wnt signal control in mammalian intestine is key to study stem cell homeostasis, cancer and tissue regeneration. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/vivian-li/.
Rising evidence suggests that targeted therapies and immunotherapies can improve treatment and survival rate of cancer patients. Immunotherapies have provided new promising therapeutic approaches to cancer treatment using our body’s natural defences. In particular, the discovery of checkpoint inhibitors has opened up exciting avenue for cancer treatment with remarkable response in cancers such as melanoma and non-small cell lung cancer. However, majority of CRCs have shown resistance to treatment with checkpoint inhibitors in the clinic. The project will focus on studying the underlying mechanism of resistance to immunotherapies in CRCs using 3D organoid models.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is at 06/02/2019 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.