Scientific Officer 2 - Clinical and Experimental Pharmacology Group

Scientific Officer 2 - Clinical and Experimental Pharmacology Group

Cancer Research UK (CRUK)

Manchester, United Kingdom

Scientific Officer 2 – Clinical and Experimental Pharmacology Group

Cancer Research UK Manchester Institute


£20,404 – £24,000 per annum (dependent upon experience)

Fixed term until 1 December 2023

Job Ref: MI/18/94

About the role

We are currently looking for a Scientific Officer within Professor Caroline Dive’s CBE Clinical and Experimental Pharmacology Group. The aim of this post is to support the day to day running of the preclinical team and carry out research under supervision as directed by the Group Leader and Preclinical Pharmacology Team Leader. You will additionally support a European-wide consortium with the goal of developing a colorectal cancer (CRC) platform for the acceleration of drug target identification, preclinical validation and clinical translation. Our focus will be on generating and making accessible models of CRC that align with the recently described human CRC molecular subtypes, and enhance the testing of CRC therapeutics in a functionally relevant microenvironment. Our primary focus is aimed at establishing patient-derived primary cell colorectal cancer models from circulating tumour cells to support a personalised medicine program.

You will generate CTC-derived models and, when successful, conduct preclinical pharmacology studies in collaboration with academic and industrial drug developers including the analysis of predictive and pharmacodynamic biomarkers. In particular, you will investigate rational drug combinations in patient derived models with a view to translating promising results towards the clinic.

About you

You should have a background in cancer biology and experience working in a laboratory, particularly using mammalian cell culture along with a relevant degree in biological sciences or related subject or equivalent relevant experience.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute (, an Institute of The University of Manchester (, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (, the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

We are partnered with The Christie NHS Foundation Trust in South Manchester (, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

To apply for this position please visit our website.

Closing date: 6 February 2019.

For any informal enquiries about this post, please contact Kris Frese at

Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK

Please apply via recruiter’s website.