CRISPR Genome Surgery in preclinical humanized mice and patient-specific stem cells
The Barbara & Jonas Stem Cell and Regenerative Medicine Laboratory at Departments of Ophthalmology, Pathology & Cell Biology at Columbia University seeks postdoctoral applicants for research with patient-specific stem cell lines: disease modeling, repair, transplantation as well as gene therapy. Other than cancer, blindness is the most feared of condition amongst Americans. Our NIH-R01EY018213, R24EY026682, R01EY024698 and R01EY026682 supported laboratory investigates cell-based treatments for neurodegenerations, and develops patient specific disease models relevant to Investigational New Drug (IND) Application – FDA. The eye is an ideal testing ground for stem cell therapies because of its relative immune privilege and its ready accessibility for monitoring and imaging purposes .
Books: Precision Medicine, CRISPR, and Genome Engineering: Moving from Association to Biology and Therapeutics . Adv Exp Med Biol. 2017;1016:1-178. Springer Nature Publishing Group;
Stem Cell Biology and Regenerative Medicine in Ophthalmology, Springer Press, NY, 2012;
Ref on CRISPR: The Journal of Clinical Investigation 2018;128(6):2177-2188. Ophthalmology 2018;125(9):1421-1430 Mol Ther. 2016;24(8):1388-1394.
Ref on Stem Cells: Human Molecular Genetics. 2014 Jan 31. PMID: 24497574; Transplantation. 89(8), 911-9. Mol Med. 2012 18:1312-9.
Ref on Gene Therapy: Proc Natl Acad Sci U S A. 2017;114(20):5259-5264.
J Clin Invest. 2018;128(6):2177–2188. J Clin Invest. 2015 Sep 1;125(9):3704-13. Human Molecular Genetics. PMID: 24101599; PMID: 23108158; J Neurosci. PMID: 23946405. Science. 272, 1026-1029 PMID: 8638127; Science. 282, 117-21. PMID: 9756475
Ref on metabolome reprogramming:. J Clin Invest. 2016;126(12):4659-4673 PMID:27841758. Hum Mol Genet. 2016 Aug 11. pii: ddw256. PMID: 27516389
Requirements: Applicants should have a PhD in enzyme kinetics, electrophysiology, cell biology, Molecular Biology or related fields. U.S. citizen/permanent residents preferred. Please email your CV to firstname.lastname@example.org.