Area of research:
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
Within the international research network AeroHEALTH the impact of atmospheric aerosols on health is investigated. Applying state-of-the-art exposure and analytical techniques, the response on different biological levels is examined to obtain more detailed information about the molecular mechanisms of effects. The adverse outcomes are analyzed after exposure to primary emissions as well as to aerosols that were artificially aged in atmospheric relevant conditions.
The Institute of Computational Biology is globally recognized for innovations in data analysis and modeling of biological systems, anchored at the Helmholtz Zentrum Munich and the Technical University Munich.
Our research group "Computation Cell Maps" focuses on data integration aspect in multi-omics and translational research. We are currently looking for aPhD candidate (f/m/diverse) in "Understanding health effects of air pollutants from physicochemical and biological high-throughput data"
The proposed research project is a corner stone of the budding research network AeroHEALTH with the focus on dissecting the impact of air pollutants on health. As the main center for data integration within this network, we are working on the interface of physics, chemistry, biology, medicine and computer science.
To identify the aerosol parameters that are critical for our health, the proposed PhD projects aims to:Developing novel methods to integrate particle composition and their omics profiles using deconvolution and statistical methods Predictive modeling of toxicity parameter from human and murine transcriptomics and epigenomics data Analyzing existing and novel data with newly developed method to identify aerosols with strong health effectsIntegration of animal model and human cell culture data to enhance translation of finding towards health effects
Your QualificationsMasters Degree in Data Science, Bioinformatics, Biostatistics, Computer science, Physics or related fieldsPassion for science and reproducible scientific workStrong interest in natural science and interdisciplinary workExperience with high-throughput data analysis, statistical analyses or machine learningExcellent Programming skills (R, Python, C/C++)Scientific curiosity and ability to work independentlyGood communication skillsFluent in spoken and written English
At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.
Remuneration and benefits are in accordance with the collective agreement for the public service (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled.
The position is (initially) limited to three years.
The activity involves special knowledge and experience specific to own scientific skills.
As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.
We are looking forward to receiving your comprehensive online application until the end of January 2019.