Postdoctoral Researchers in platelet and megakaryocyte biology

Postdoctoral Researchers in platelet and megakaryocyte biology

University of Würzburg / Institute of Experimental Biomedicine

Würzburg, Bavaria, Germany

The Department of Experimental Biomedicine at the Rudolf Virchow Center/University Hospital Würzburg invites applications for

3 Postdoc positions (f/m/d)

Platelet activation at sites of vascular injury is essential for hemostasis, but in diseased vessels it can also lead to ischemic events, such as heart attack and stroke. Moreover, the interaction of platelets with cells of the immune system (“thrombo-inflammation”) is critically involved in the pathogenesis of inflammatory disease states. The production of platelets by their bone marrow precursor cells, the megakaryocytes, is tightly controlled and disturbances in this process may result in hemorrhagic disorders and vascular defects.

We focus on transgenic mouse models to study the roles of regulatory proteins (receptors, signaling molecules, cytoskeletal components) for platelet production and function in vitro and in vivo. Our research will yield novel insights into the process of platelet biogenesis and the complex functions of platelets in cardiovascular disease. Our long-term goal is to identify novel targets for the development of improved therapies against vascular diseases.

We are seeking excellent Postdocs to work on the following research topics:

1) Mechanisms of megakaryocyte polarization and platelet biogenesis
2) Signal transduction in platelet adhesion
3) Protein-protein interaction in platelet receptor signaling

Activities and responsibilities

The projects 1) and 2) will include the use of cutting edge in vitro and in vivo imaging techniques, cell biology, molecular biology, biochemistry, disease models and mouse genetics, and will have a strong biomedical/translational context. Project 3) will focus on biochemical analyses of protein-protein interaction, characterization of receptor-ligand interaction and protein engineering for preclinical therapeutic approaches. As a postdoctoral fellow in our group you will drive your own research project and collaborate closely with other group members, as well as local and international collaboration partners. You will furthermore engage in (co-)supervising PhD students and teaching activities.

You have / Qualification profile

Suitable candidates should hold a doctoral degree in biomedicine, pharmacy, biochemistry, biology or a related field and have a strong interest in molecular and (vascular) cell biology/immunology, mouse models, different imaging techniques, as well as translational disease-oriented research. Excellent knowledge of the English language is a prerequisite. For positions 1) and 2) previous experience with genetic mouse models, preferably in the field of vascular biology, is highly advantageous. For position 3) we seek an applicant with previous experience with (preferably mammalian) expression systems, protein purification and structural biology. As a postdoc in our group you should be able to drive and contribute to research projects and independently develop new research ideas.

Why join us / Benefits

All projects are embedded in the collaborative research center/transregio CRC/TR 240 – “Platelets – Molecular, cellular and systemic functions in health and disease” funded by the German research foundation (DFG) which provides a research environment and infrastructure that is unique in the platelet field. The projects furthermore involve the close interaction with long-standing international collaboration partners.

Our department is situated within the Rudolf Virchow Center, an international research center of the University of Würzburg which is part of the Medical Campus of University Hospital Würzburg. The Center provides an inter-disciplinary working environment using state-of-the-art infrastructure. The university offers also a comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg), the International Office, the Family Services as well as the JMU Research Academy (professional support and development) (see www.platelets.eu/career/).

The salary for these positions is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L. The positions are initially limited for two years with the possibility of extension. We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to

The positions will start on March 1st, 2019 or later. Applications should be sent as one single pdf-document including application letter, curriculum vitae, certificates and 3 references by e-mail until February 15th, 2019 to

The Würzburg Platelet Group / Prof. Bernhard Nieswandt (career@platelets.eu)

Please see our homepage (www.platelets.eu/career/) for further details on the positions.

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Position

Postdoctoral Researchers in platelet and megakaryocyte biology