Postdoc: Molecular mechanisms in regulation of chronic inflammation

Postdoc: Molecular mechanisms in regulation of chronic inflammation

Univerzita Palackého v Olomouci

Olomouc, Czech Republic

Postdoc: Molecular mechanisms in regulation of chronic inflammation.

Our group at the Faculty of Medicine, Palacky University Olomouc (Czechia) has been investigating the role of mediators and their receptors in the pathogenesis of chronic inflammation including their genetic determination and regulation. Currently, the epigenetic mechanisms, e.g. miRNA, have been investigated and bioinformatics approaches have been implemented. Translational potential of this research has been reflected and applied to respiratory, endocrine and cardiovascular disease. Recent techniques such as NGS, SNP genotyping by MassArray, microarrays etc. have been utilized. The group lead by Prof Martin Petrek is part of several international research projects.

Recent papers from the laboratory (a selection):

Kishore et al. Expression analysis of extracellular microRNAs in bronchoalveolar lavage (BAL) fluid from patients with pulmonary sarcoidosis. Respirology, December 2018. doi: 10.1111/resp.13364 (paper advertised on the Journal cover page)

Karakaya et al. Bronchoalveolar lavage characteristics correlate with HLA tag SNPs in patients with Löfgren’s syndrome and other sarcoidosis. Clinical and Experimental Immunology, 2019 – in press. (collaboration with researchers in the Netherlands)

Petrkova et al. Pharmacogenetics of Cardiovascular Disease: Genetic Variation and Statin Intolerance, 127-141 (Chapter 7). In: Genetic Diversity and Disease Susceptibility. November 2018 DOI: 10.5772/intechopen.79518

Kishore and Petrek. Next-generation sequencing based HLA typing: deciphering immunogenetic aspects of sarcoidosis. Frontiers in Genetics, October 2018. doi: 10.3389/fgene.2018.00503

Tokić et al. miR-29a-3p/T-bet regulatory circuit is altered in T cells of patients with Hashimoto’s thyroiditis. Frontiers in Endocrinology, June 2018. doi: 10.3389/fendo.2018.00264

Wolin et al. SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility – A Joint Analysis in Four European Populations. Frontiers in Immunology, 2017. doi: 10.3389/fimmu.2017.00422 (international collaboration)

Arakelyan et al. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Frontiers in Genetics, 2016 http://dx.doi.org/10.3389/fgene.2016.00079 (international collaboration)

The University and the city of Olomouc

Despite its tradition (founded in 1573), Palacky University (http://www.upol.cz) is a thriving institution with cutting edge facilities especially in area of biological and medical sciences. Faculty of Medicine and Dentistry (https://www.lf.upol.cz/en/scienceand-research/science-and-research/) is the second Czech institution according to research output just after Prague Charles University. The biomedical research here benefits from partnering with Olomouc University Hospital, one of the biggest tertiary referral centers in Czechia, and also with the Institute of Molecular & Translational Medicine (http://www.imtm.cz/) , a top Czech research centre.

Olomouc (www.olomouc.eu) is a historical city, sometimes titled “small Prague”. With its one hundred thousand inhabitants plus more than twenty thousand students it is lively, but still very pleasant place to live with ample opportunities for socializing, culture and sport activities. Most places are within walking distance, still with efficient and cheap public transport, bike service available as well. The living in the city is affordable, also due to fact that prices in many areas are far from Western Europe levels.

The candidate

You should be creative, responsible and open to team work. A doctoral (Ph.D. or equivalent) degree in Biomedical Sciences (e.g. Immunology, Genetics, Cell Biology or Biochemistry etc.) is expected. Previous experience in biomedical / translational research is desirable. Expertise in gene expression profiling, sequencing, bioinformatics is a plus. English is the communication language. The position offers a competitive salary according to the Czech academic salary standards.

Application

Please consult the details of application online (https://www.euraxess.cz/jobs/295224). The post is initially for 18 months with possibility of extension for another 18 months period (3 years in total). Start date is flexible within period from 1st February to 1 May 2019. For informal inquiries please contact: martin.petrek2@fnol.cz, preferably by 10th January 2019.

Applications will be reviewed on a rolling basis. Any application received by 25th January 2019 will be considered.

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Postdoc: Molecular mechanisms in regulation of chronic inflammation