We are looking for a Principal Scientist with a strong research background in psychiatric disorders and molecular biology training to join the Lundbeck Research Neuroscience organization in the department for Signal Transduction. As part of the larger Lundbeck R&D organization, we are focused on utilizing molecular and cellular neuroscience to establish the pharmacodynamic mechanisms of drug candidates at the cellular level and to continuously develop our understanding of disease biology and therapeutic entry points.
Your job and key responsibilities
- With your in-depth understanding of psychiatric disorders and with your firm grasp of genetics, molecular and cellular biology you will contribute with scientific leadership and key experimental data to guide and ensure the progression of drug discovery projects.
- You will work closely together with fellow cellular and molecular biologists and technicians as well as geneticist and bioinformaticians across the organization to establish experimental testable hypotheses that allow you to interrogate target biology and pharmacological effects in immortalized cell lines, primary cells and native tissue. You will do this both in house and by leveraging on external partnering opportunities.
- Experimentally, you focus on measuring target function and dynamics, second messenger signaling, changes in gene-expression and protein network signaling to establish and measure pharmacodynamic effects in pursuance of target validation, drug candidate selection and establishment of therapeutic index.
- A significant part of your job is to evaluate new project opportunities and disease hypotheses together with our colleagues from research and development, and to deliver input to the scoping of new drug discovery projects.
- You proactively seek to extend the drug discovery utility of innovative technologies that inform on target signal transduction at the omics scale (example RNA sequencing)
- You communicate ideas, plans, results in a clear and concise fashion; project leadership experience is an advantage.
The opportunity to join a team of highly qualified and experienced colleagues that are on a quest to discover and make novel and innovative medicines for patients with psychiatric illnesses and to share a workplace with an open, science-driven, collegial and collaborative atmosphere. We focus on teamwork and individual professional development and you will be part of a global and specialized pharmaceutical company with approximately 5,000 employees focused on helping patients with psychiatric and neurological disorders.
Our preferred candidate has the following professional and personal qualifications:
- PhD in a relevant life science discipline with post-doctoral experience in neuroscience (academia or industry)
- Insight into psychiatric and CNS-related diseases
- 5+ years in pharmaceutical research, alternatively a strong academic track record in the field of molecular psychiatry
- Experience with a broad range of in vitro assay techniques and extensive experience in establishing and using cellular disease mechanistic models to probe cellular signalling and phenotypes
- Broad experience with target classes such as GPCR’s, ion channels and enzymes and modalities such as small molecules, peptides and antibodies
- Demonstrated ability to establish and engage in external collaborations (consortia, academic collaborations or CRO’s)
- Experience with leading project focused teams
- Strong data analysis and data visualisation capabilities
- Strong organizational, collaborative and team-player skills
- Strong communicator in English, written and orally.
For further information, please contact Director Ib Vestergaard Klewe on email@example.com or through +45 36301311. Your application and CV should not be sent via email. We also recommend that you have a look at our website.
Please click on the link below to apply for the job. Applications must be received no later than Monday 25th of January 2019.