About the team/job
An exciting opportunity has been created for a talented bioinformatician to work on methods for the annotation of drug discovery relevant data. The position is funded by the Open Targets initiative which is a public-private initiative between EMBL-EBI, GlaxoSmithKline, Biogen, Takeda, Celgene, Sanofi and the Sanger Institute to generate and integrate evidence on the validity of biological targets for drug development.
Based in the ChEMBL Team at the European Bioinformatics Institute (EMBL-EBI) the appointee will work with the Open Targets partners to develop pipelines for the identification and integration of information and data to support the role(s) of biological targets in disease into the Open Targets Platform
Reporting to the ChEMBL team leader, you will have excellent attention to detail, strong communication skills and be able to interact with technical experts as well as scientists seeking solutions to their "real world" problems. The specific job responsibilities include:
- To extend and validate pipelines for identifying target to drug to disease links by utilising a variety of resources such as ChEMBL, clinical trials data, the scientific literature and patents;
- Curate the potential therapeutic targets of drug molecules and compounds in clinical development from a variety of sources such as the scientific literature, Pharma Company pipelines and prescribing information;
- Carry out mapping of disease terms to existing public ontologies;
- Develop a text mining pipeline to identify and extract clinical trials outcomes from public data sources;
- Work with the Open Targets partners to assess, validate and refine the resulting methods;
- To work with Open Targets core team to integrate the data into the Open Targets Platform.
- A PhD (or equivalent) in a biological or biomedical science.
- Sound knowledge of disease biology and the mechanisms of drug action.
- Proficiency in at least one programming/scripting language (e.g. Python, Perl etc).
- Experience in data handling, manipulating file formats and working with ontologies
- Ability to work accurately and quickly to deadlines.
- Able to work both as part of a team and independently
- Good communication skills (both verbal and presentational)
You might also have
- Experience of biological data curation and knowledge of bioinformatics databases
- Experience working with clinical trials or drug candidate data
- Experience working in a drug discovery and development environment.
Why join us
At EMBL-EBI, we help scientists realise the potential of ‘big data’ in biology by enabling them to exploit complex information to make discoveries that benefit mankind. Working for EMBL-EBI gives you an opportunity to apply your skills and energy for the greater good. As part of the European Molecular Biology Laboratory (EMBL), we are a non-profit, intergovernmental organisation funded by 22 member states and two associate member states. We are located on the Wellcome Genome Campus near Cambridge in the UK, and our 600 staff are engineers, technicians, scientists and other professionals from all over the world.
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation. For more information about pay and benefits click here
We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.
If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.
What else do I need to know
To apply please submit a covering letter and CV through our online system.
Applications are welcome from all nationalities and this will continue after Brexit. For more information please see our website. Visa information will be discussed in more depth with applicants selected for interview.
EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.
This position is limited to the project duration specified.
Applications will close at 23:00 GMT on the date listed above.