PostDoctoral Associate

University of Miami Health System

Miami, FL, United States

A post-doctoral position is available in the Department of Human Genetics, University of Miami, Florida for a translational research project studying epigenetic drivers of AML and MDS. The laboratory focuses on studying the contribution of DNA methylation changes to the development of acute leukemias and other myeloid malignancies. Our previous work demonstrated that leukemias have very specific DNA methylation patterns that correlate with molecular and clinical features (Cancer Cell 2010 Jan 19;17(1):13-27; PLoS Genetics 2012 Jun;8(6); J Clin Invest. 2013 Jul 1;123(7):3099-111; Blood 2013 Oct 3;122(14):e33-43.). Furthermore, we have established a mechanistic link between known mutations in AML and the establishment of aberrant hypermethylation profiles linking metabolism and cancer (Cancer Cell. 2010 Dec 14;18(6):553-67; Cell Rep. 2014 Dec 3. pii: S2211-1247(14)00958-9, Cancer Discovery 2017 Aug;7(8):868-883).

We are currently seeking a highly motivated postdoctoral fellow with in-depth knowledge and extensive skills in cellular and molecular biology to join the lab. The candidates should demonstrate expertise in various lab techniques including cell culture and molecular biology assays (molecular cloning, cell proliferation assay, subpopulation analysis by FACS, stable and transient transfection, use of shRNA and viral constructs), preparation and analysis of DNA and RNA (prepa ration of plasmids, regular PCR and RT-PCR), chromatin immunoprecipitation (ChIP) assays, biochemical assays (ELISA, immunoblotting, Co-IP). Prior experience in epigenetics is preferred but not required. Prior experience in hematopoiesis/leukemia models, molecular biology, cancer genetics or epigenetics, and/or development of animal models is required. It is expected that the candidate will have the ability to work independently, design experiments with appropriate controls, collect and tabulate data, publish and present results, as well as to participate in the training of graduate and rotation students in a research laboratory setting. Projects will include in vivo and in vitro modeling of candidate genes to identify epigenetically silenced genes that contribute to the development of hematopoietic malignancies and characterization of candidate genes using in vitro and in vivo systems.

MINIMUM QUALIFICATIONS:

Ph.D. in cellular and molecular biology, cancer biology or related fields. Experience in a research laboratory setting. Evidence of scholarly ability (record of publication in peer-reviewed journals, etc.) Ability to communicate in written and spoken English is absolutely required. Applications should include full curriculum vitae, publication list, information on years of experience in research and laboratory work. Three reference letters, one of them from the Ph.D. advisor, are required. These must be emailed directly by the referees to the email address below. Applications without references will not be considered

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Position

PostDoctoral Associate