Postdoctoral studies in Epigenetics and chromatin remodelling

Postdoctoral studies in Epigenetics and chromatin remodelling

Karolinska Institutet (KI)

Huddinge, Sweden

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 300 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Division
Epigenetics is the study of heritable changes for example chromosomal states, which are not associated with changes in the DNA sequence. The Ekwall group,  https://ki.se/en/bionut/epigenetics-chromatin-remodelling-and-cancer-karl-ekwall, is using a variety of approaches including genome-wide analysis of epigenetic states 'epigenomics', cell biology and biochemistry to address important questions about epigenetic regulatory mechanisms such as histone modification, nucleosome remodeling and nuclear organization. Translational medicine aspects of the research are exploited mainly in the areas of cancer and cell differentiation.

Duties
We are looking for a Postdoctoral fellow which will be financed by a scholarship. The postdoc will carry out a research project using human cell lines. Furthermore the candidate will be responsible for analysis of epigenome changes resulting from gene knock-outs, especially aspects of chromatin remodeling and changes in transcription and chromatin structure.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Qualifications
We are looking for a person with solid experience of laboratory work using microscopy, biochemistry and molecular biology. Also theoretical and practical knowledge of chromosome biology research is required. The candidate needs to have meriting experience, be well acquainted with cell culture, CRISPR-Cas9 gene editing, ChIP-seq, RNA-seq methodology and basic bioinformatic analysis. Hi-C methodology and more advanced bioinformatics are also a merit.Good communication and writing skills in English are required.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. 

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Karolinska Institutet is one of the world’s leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country’s broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with temp agencies and recruiters, as well as those selling additional job announcements.

Please apply via recruiter’s website.

Quote Reference: Karolinska Institute-Karolinska-Institute-2-6919/2018

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