Salary: Grade 7: £32,236 - £39,609 p.a.
Professor Peter Somogyi would like to appoint a Postdoctoral Scientist in the Department of Pharmacology to join a project on the molecular and physiological characterisation of behaviour-dependent changes in the activity and transcriptome of identified neurons in the septo-hippocampal-prefrontal cortex network. Distinct cell types of the medial septum diagonal band nuclei modulate the interactions of the temporal and prefrontal cortices in rodents and humans. In vivo multi-site recordings of synaptically related neurons with the temporal relationship of their interactions with other systems in the brain and analysis of their behaviour-dependent changes will lead to major insights into brain mechanisms of mnemonic processes.
Experience in in vivo recording and juxtacellular labelling of single neurons in behavioural tests of rodents together with multichannel recording and microscopic analyses are essential. Experience in in situ RNA sequencing and genetic probe design, the processing of rodent and human tissues for molecular analyses would be advantages. Key duties of the post include: testing hypotheses and analysing data from in vivo electrophysiological recordings of visualised neurons, reviewing, refining working hypotheses as appropriate and making discoveries. The successful candidate will have a relevant PhD/DPhil, or submitted her/his thesis for examination by the time of appointment, and manage their research and co-ordinating multiple aspects of work. The postholder will also provide guidance to less experienced members of the research group, including postdocs, research assistants, visitors, technicians, and PhD and project students.
Evidence of designing summaries of research results, illustrations for papers and a proven ability to contribute ideas for research projects within the programme of cortical synaptic communication are necessary.
The post is fixed-term for 3 years, funded by the Wellcome Trust and the European Research Council.
The closing date for applications is 12.00 noon on Friday 4 January 2019.