Salary: Grade 7: £32,236 - £39,609 p.a.
We are seeking to appoint a Postdoctoral Research Associate to advance a new generation of protein interactions. SnoopLigase is a genetically-encoded system able to form an irreversible covalent bond between two peptide tags. Applications of our Ligase so far are in accelerating generation of vaccines, relevant to both infectious diseases and personalised medicine, and arming antibodies for cancer immunotherapy. Cyclization using SnoopLigase also shows potential for major increases in resilience of enzymes, as needed in nutrition and green chemical transformation. This project will apply novel library-based selections and rational design to advance SnoopLigases speed, sensitivity, and activity in different regions of bacterial and mammalian cells. There will then be the opportunity to apply SnoopLigase to enhance one project of special interest to the appointee. The Howarth group are currently working on areas including vaccines for global health challenges, immuno-oncology, and therapeutic targeting in the blood and GI tract. We will provide training in unfamiliar methods.
You should hold a PhD/DPhil, or expect to obtain soon, a PhD/DPhil in biochemistry, immunology, cell biology or a related area. You will have experience in molecular biology approaches and recombinant protein expression and have excellent communication skills, with the ability to write for publication and present research proposals and results. Skills in library-based selection, structure-based engineering of proteins, or flow cytometry are advantageous but not essential.
This full-time fixed-term post is funded by BBSRC for up to 3 years in the first instance and is based at the Department of Biochemistry, South Parks Road, Oxford.
The actual starting salary will be based on qualifications and relevant skills acquired and will also be determined by the funding available. This is unlikely to be more than £34,189 p.a.
Further particulars, including details of how to apply, can be obtained from the document below.
The closing date for applications is 12.00 noon on Thursday 3 January 2019, with interviews for shortlisted candidates to be held as soon as possible thereafter.