Postdoctoral Fellow - Structure-Based Drug Discovery by Private/Public Partnership

Postdoctoral Fellow - Structure-Based Drug Discovery by Private/Public Partnership

European Molecular Biology Laboratory (EMBL)

Hamburg, Germany

About the team/job

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes of medical relevance. Our main research interest is on structures of large protein translocation systems and the investigation of molecular parameters leading to elastic properties in giant muscle proteins. We collaborate with several clinical groups with interests in infectious diseases, cancer and hereditary diseases. Most of our projects require integrative structural biology methods including X-ray crystallography, electron microscopy and complementary biophysical approaches, generally followed by functional experiments.

Your role

The development of novel therapeutic strategies is essential to combat the highly infectious pathogen Mycobacterium tuberculosis (Mtb). The aim of this project is to structurally and functionally characterize a new toxin-antitoxin system (TA) with bactericidal activity in Mtb, to reach an in-depth mechanistic understanding of the toxin activity and molecular parameters that modulate the TA assembly. Together with an industrial partner, we will use this knowledge to chemically trigger the disassembly of the cidal toxin from its inactivating protein antidote using small molecule interference. The project provides an unique opportunity for you to work in a private/public partnership between academia and industry.

You have

Applicants should have a PhD in a relevant field, proven record of scientific accomplishments, international experience, scientific ambition and excellent communication skills, project coordination, and previously demonstrated expertise in X-ray crystallography, biochemistry and biophysical approaches including sample preparation (molecular biology, heterologous expression, protein purification).

You might also have

Additional expertise in biochemistry (in vitro and cell-based assays) and cell biology (including imaging) would be advantageous.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. Scientists at the EMBL Hamburg Unit benefit from cutting-edge technology to accommodate their research, with on-site synchrotron radiation beamlines operated by EMBL and opportunities for collaboration with colleagues from all six EMBL units.

What else do I need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Informal inquiries should be sent to:

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

Please apply via recruiter’s website.

Quote Reference: EMBL-embl-HH00161