Postdoctoral Fellow - Structure Biology of Proteins Crystallized in Cells

Postdoctoral Fellow - Structure Biology of Proteins Crystallized in Cells

European Molecular Biology Laboratory (EMBL)

Hamburg, Germany


About the team/job

The research group of Matthias Wilmanns has a long-standing record in structural biology on research themes of medical relevance. Our main research interest is on structures of large protein translocation systems and structural dynamics of giant muscle proteins. We additionally collaborate on specific research projects with several clinical groups with interests in tuberculosis, cancer and hereditary diseases. Most of our projects require integrative structural biology methods including X-ray crystallography, electron microscopy and complementary biophysical and biochemical approaches. The group shares expertise and research infrastructures with other EMBL research groups in Hamburg.


Your role

This project aims to apply and expand recently established techniques to determine novel structures of proteins and protein complexes from crystals grown directly in eukaryotic cells. You will apply those to ongoing projects of high scientific and medical relevance from our research group (for further details, see www.embl-hamburg.de/research/unit/wilmanns/ and recent publications). In a further step, we are aiming to use these crystals for time-resolved structural studies to investigate biological function. The project is supported by an international consortium, which provides ample opportunities for exchange, collaboration and multidisciplinary training. For structure determination, we offer access to leading structural biology beamlines operated by the EMBL Hamburg Unit, nearby beamline facilities operated by the European X-ray Free Electron Laser, as well as partner facilities in Sweden.


You have

You should have a PhD in a relevant field, proven record of scientific accomplishments, international experience, scientific ambition and excellent communication skills, and previously demonstrated expertise in X-ray crystallography and biophysical approaches including sample preparation (molecular biology, heterologous expression in eukaryotic hosts, protein purification).


You might also have

Additional expertise in biochemistry (in vitro and cell-based assays) and cell biology (including imaging) would be advantageous.


Why join us

Why not? Well, EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits. Scientists at EMBL Hamburg benefit from cutting-edge technology to accommodate their research, with synchrotron radiation (PETRA III) and laser (FLASH) facilities available. Additionally, possibility of collaboration with colleagues from other EMBL units.


What else do I need to know

We are Europe’s flagship research laboratory for the life sciences – an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1600 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.

Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research.

Further comments: Informal inquiries should be sent to: wilmanns@embl-hamburg.de.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

Please apply via recruiter’s website.

Quote Reference: EMBL-embl-HH00156

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