Topic: Cross-talk of DNA replication stress and mitotic dysfunction
Three positions are available within the newly founded research consortium FOR2800 “Chromosome Instability: Cross-talk of DNA replication stress and mitotic dysfunction” (www.for2800.de). The research is focused on understanding the interplay between DNA replication and chromosome missegregation and their contribution to genome instability and to various pathologies, such as cancer, aging and neurodegenerative diseases. Payment will be according to German standard levels (TV-L), the employment is initially envisioned for three years.
Structural and numerical chromosomal aberrations are frequent in cancer and other human diseases. One important condition that leads to structural chromosomal aberrations is “replication stress”, a perturbed DNA replication that interferes with timely and error-free completion of the S-phase, thereby leading to stalled or slowly progressing replication forks. On the other hand, mitotic errors that result in chromosome missegregation are the cause of chromosome copy number changes – aneuploidy. Since structural and numerical instability are often detected concomitantly, these two forms of chromosomal instability might be mechanistically interlinked. The projects are part of the Collaborative Research Center FOR2800 (www.for2800.de) fully funded by the German Research Foundation (DFDG), providing exciting opportunities for highly innovative research and tight collaborations among several research groups working on related topics.
There are three positions available:
1. Postdoc or PhD Student in Computational Systems Biology (Group Maik Kschischo) at the University of Applied Sciences Koblenz, Germany. The goal is to develop new statistical and machine learning methods and algorithms to better understand complex and high dimensional data and to contribute statistical and computational modelling toward a biological understanding of chromosomal instability. Please send your application under the subject “FOR-2800-Postdoc-Kschischo” or „FOR-2800-PhD-Kschischo“, respectively.
2. PhD Student in the Department of Molecular Genetics at the Faculty of Biology, TU Kaiserslautern, Germany. The PhD candidate will join the group of Zuzana Storchova to analyze the molecular mechanisms that link chromosome copy number changes and replicative stress in human cells. Please send your application under the subject „FOR-2800-PhD-Storchova“. Contact: email@example.com
3. PhD Student in the group of Markus Raeschle in the Department of Molecular Genetics at the Faculty of Biology, TU Kaiserslautern, Germany. The PhD candidate will use the state-of-the-art proteomics approaches to uncover chromatin-binding proteins that are required for resolution of replicative intermediates in mitosis. Please send your application under the subject „FOR-2800-PhD-Raeschle“. Contact: firstname.lastname@example.org
The respective candidates will be part of structured graduate schools at the respective universities and will actively participate in the activities of the research consortium, which provide additional benefits including additional method and career development courses.
We are looking for highly motivated and team-oriented PhD students. The applicant should have a master degree in a relevant subject (physics, chemistry, biophysics, biotechnology, bioinformatics, biology or a related subject). Please send your full application to above specified contacts until January 15, 2019 and include as a single PDF your CV, motivation letter, all academic certificates (including all course records) and the names of two references who are willing to write a letter of recommendation upon request. We request that you send us copies of your documents, as no returns will be made. We will destroy the documents after a holding period of five months.