Research Fellow

Research Fellow

University College London (UCL)

London, Greater London, United Kingdom

Division of Biosciences

UCL Research Division of Genetics, Evolution and Environment London

Research Fellow

Full Time

The appointment will be on UCL Grade 7.

The salary range will be £35,328 – £42,701 per annum, inclusive of London Allowance.

We are recruiting a post-doctoral Research Fellow to investigate how mitonuclear interactions affect drug responses and stress in Drosophila melanogaster. We use the Drosophila model as it is a very clean system to test interactions between mitochondrial and nuclear genomes. In the lab we have fly lines with either coevolved or mismatched mitonuclear genomes. Using this system we want to test the effects of mitonuclear mismatches on mitochondrial function, metabolic flux, gene expression and phenotype (fitness, activity and survival) under different drug or stress regimens. The post holder will be an important member of the research team, and will be responsible for the design and carrying out of experimental work, its analysis and presentation, and preparation of material for publication. The post-holder will be expected to produce independent, original contributions to the subject area.

The position is grant funded and is available from the 1st of January 2019 for 3 years in the first instance with the possibility of extension.

The successful candidate will have a PhD (or about to submit) in a relevant discipline. The applicant should have a strong background in biochemistry and bioenergetics, with expertise in the use of high-resolution tissue respirometry, ideally using an Oroboros. Expertise in redox signalling would be valuable. The successful candidate should also have skill in planning and executing large phenotypic Drosophila experiments and be able to collect/analyse the data. The applicant will need a good understanding of mitochondrial biology, with an interest or background in metabolomic profiling and modelling metabolic flux. The successful applicant would work alongside another Research Fellow with skills in phenotypic work in Drosophila, gene expression and bioinformatics.

Please note: Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at research assistant Grade 6B (Salary £30,922 – £32,607 per annum, including London Allowance) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).

UCL vacancy reference: 1768917

Applicants should apply online. To access further details about the position and how to apply please click on the ‘Apply’ button above.

For informal enquiries about the post please contact Professor Nick Lane at If you have any queries regarding the application process please contact Biosciences staffing on quoting the vacancy reference number: 1768917.

Closing Date: 28 December 2018

Latest time for the submission of applications: 23:59.

Interview Date: TBC

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