Job title: Senior Laboratory Research Scientist
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 1-year maternity cover
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 9348
The position is for a 1-year maternity cover for an experienced scientist to study the mechanisms leading to congenital heart defects in Down Syndrome using mouse genetics. The post-holder would report directly to Victor Tybulewicz, the Group Leader, and would be expected to work closely with other members of the group, and with external collaborators.
Down Syndrome (DS), trisomy 21, is a common genetic condition resulting in a large number of different phenotypes, including cognitive impairment, early-onset Alzheimer’s disease and congenital heart defects. These phenotypes result from an increased dosage of one or more of the ~230 genes on human chromosome 21 (Hsa21). However, the identity of the gene(s) causing these phenotypes, and the resulting pathological mechanisms are largely unknown.
Research in the group is focussed around understanding the genetic, cellular and biochemical mechanisms resulting in DS phenotypes. To do this we have generated a series of mouse models with duplications of regions of the mouse genome orthologous to Hsa21, thereby resulting in mice with three copies of different sets of genes (Lana-Elola et al, eLife 2016). These mouse strains have a number of DS-related phenotypes, and comparison of the different strains is allowing us to home in on the location and identity of the causative genes. In addition, we are using the mouse models to investigate mechanisms that lead to pathology.
The person in this position will study the genes and mechanisms that lead to congenital heart defects (CHD) in DS. They will generate novel genetically altered mouse strains using CRISPR-based methodology and phenotype embryonic CHD from various mutant mouse strains using high-resolution episcopic microscopy and 3D-modelling. In addition, they will study pathological mechanisms using a variety of techniques which could include histology, multi-photon and light sheet imaging, transcriptomics and proteomics.
The person will join a group of around 12 researchers, 5 of whom work on Down Syndrome. They will be expected to work closely with these researchers as well as a number of external collaborators.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 17 December 2018 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.