Postdoc position Analysis of the MHC class I ligandome during bacterial infection and contribution of posttranslationally modified peptides to immune defense (1.0 FTE)

Postdoc position Analysis of the MHC class I ligandome during bacterial infection and contribution of posttranslationally modified peptides to immune defense (1.0 FTE)

Utrecht University

Utrecht, Netherlands

Postdoc position Analysis of the MHC class I ligandome during bacterial infection and contribution of posttranslationally modified peptides to immune defense (1.0 FTE)

Job description
We are looking for a highly motivated Postdoc to work on a project funded by the Netherlands Organisation for Scientific Research (NWO), to determine to which extent proteasome-mediated post-translational peptide modification plays a shaping the antigenic landscape on cells infected with intracellular pathogens. The post doc will join the group of Alice the Immunology Division of the Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Research by this focuses on the cellular mechanisms underlying immune defense against intracellular pathogens, with the aim to translate obtained knowledge for development of next generation vaccines.

Project description
In how many flavors does the MHC peptidome come? In this project you will combine immunological, biochemical and computational biological, bioinformatics expertise to unravel the representation of a ‘novel’ peptide species, generated proteasome-mediated peptide fusion, (i.e. spliced peptides) within the MHC peptidome on infected cells. You will address mechanisms underlying generation of spliced peptides, and use a preclinical model to examine their immunological relevance.

Your responsibilities will include the design and execution of experiments based on leads from a previous project, communication with international collaborators, data analysis, and manuscript preparation. In addition, you will have opportunity to co-supervise several PhD students. You are expected to develop novel ideas and have the ambition grant applications to support your future career.

Qualifications
We seek an experienced and ambitious immunologist/biochemist at the Postdoctoral level with an interest in fundamental research, and the drive to pursue a multi-disciplinary project. Excellent organisational and communicative skills and to work both independently and as part of an (inter)national team are an asset.

Requirements

  • PhD in Cell Biology, Biochemistry or Immunology;
  • Expertise in molecular biological, biochemical and/or immunological techniques;
  • Record of relevant peer-reviewed publications;
  • Excellent English oral, written and presentation skills;
  • Ability to think critically and creatively.

Offer
We offer a fulltime position, initially for a period of a year, with the possibility of extention. The gross monthly salary is based on experience and qualifications, and ranges from a minimum of €3,123 to a maximum of €4,138 (i.e. salary scale 10 or 11 according to the Collective Labour Agreement for Dutch Universities) on a fulltime basis. Salaries are supplemented with a holiday allowance of 8% and a year-end bonus of 8,3%. Utrecht University offers excellent secondary benefits including collective insurance schemes, an excellent pension scheme and flexible employment conditions. For more information: Working at Utrecht University.

About the organization
A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University the various disciplines collaborate intensively towards major societal themes. Our focus is on Dynamics of Youth, Institutions, Life Sciences and Sustainability.

The Faculty of Veterinary Medicine has a unique position in the Netherlands. Not only is this the only institution where veterinarians are trained, researchers are also working together on innovative scientific research. In addition, the faculty provides specialist clinical care in the largest academic veterinary hospital in Europe. Thanks to this position, the Faculty of Veterinary Medicine is a point of contact for all veterinary matters, both nationally and increasingly internationally. The Faculty employs approximately 900 veterinarians, scientists and support staff and counts 1,500 students.

The group of Alice Sijts is located in the Immunology Division of the Department of Infectious Diseases and Immunology of the Utrecht University Faculty of Veterinary Medicine. Her group participates faculty’s research focus “One Health” and in the “Research Center for Infection and Immunity”, which joins research Infectious diseases, Microbiology, Inflammation and Immunology within the broader Utrecht area.

Additional information
For more information, please contact Alice Sijts (Associate Professor of Immunology), via e.j.a.m.sijts@uu.nl or 00 31 30 253 24 71.

Apply
To apply, please send your curriculum vitae, including a letter of motivation via the apply button below.

The application deadline is
21/12/2018

Please apply via recruiter’s website.

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