Job title: Postdoctoral Training Fellow
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term (4 years), full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 8266
An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science. A postdoctoral research post in the laboratory of Caroline Hill is now available. Work in the Hill lab is focused on understanding how TGF-β superfamily signalling pathways function normally in early vertebrate development and in adult untransformed tissue culture cells, and how these signalling pathways are perturbed in disease, in particular, cancer. The lab has been exploiting the very powerful combination of early vertebrate developmental systems (primarily zebrafish embryos), together with a variety of model tissue culture systems, and uses methodologies ranging from developmental and cell biology to computational modelling.
The project will focus on the question of how long-term Nodal/Activin signalling specifies cell fates, in particular how it is involved in the decision governing the specification of mesodermal versus endodermal fates. The primary system to be used will be mouse ES cells, and the project will follow up some provocative findings resulting from deleting specific Smad proteins in these cells. The work will complement similar questions being addressed in the lab using the zebrafish embryo.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 03 January 2019 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.