Helmholtz Pioneer Campus
Area of research:
Scientific / postdoctoral posts
Contract time limit:
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The Helmholtz Pioneer Campus (HPC) is an innovation campus with a startup culture, founded and funded by the Helmholtz Zentrum München. HPC stands for the smart fusion of biomedical sciences, engineering and digitization in a research environment that has no parallel in Europe.
The Molecular Ageing Team headed by Dr. Celia Martinez-Jimenez is offering
Our laboratory aims to compare “molecular age” (predicted by molecular features such as DNA methylation, chromatin accessibility and cell-to-cell transcriptional variability) with “chronological age” (defined by the biological age of a given individual). Distinct molecular features will be used to decipher the impact of cellular variability on tissue function(s) during ageing and chronic disease.
We pursue an integrative and collaborative approach, working closely with other groups at the Helmholtz Zentrum München. Experimentally, we combine single-cell genomics (transcriptomics, epigenomics and metabolomics) to study how ageing impacts individual cells, tissues as well as health and functionality of the whole organism.
We are seeking postdoctoral research fellow(s) with strong organisational skills, self-driven to work independently, and with a positive and collaborative attitude to engage with biomedical, computational and clinical scientists. Your studies will employ cutting-edge functional genomics, experimental models and computational analyses (in collaboration with the Institute of Bioinformatics and Systems Biology - IBIS).
Candidates should have strong experimental skills in either functional genomics and/or molecular biology. It is essential to have proven experience with in vivo models including FELASA or equivalent certification. Experience in liver biology and FACS sorting is desirable. Applicants should hold, or about to be awarded, their PhD with an excellent publication record (including at least one first author, peer-reviewed research paper).
Specific skills to be acquired during completion of the projectProficiency in cutting-edge functional genomics, experimental models and computational analyses (in collaboration with the Institute of Bioinformatics and Systems Biology - IBIS)Experience in molecular biology and tissue culture techniquesDevelop and maintain mouse models and ageing colonies (including wild type and knock out mice)Develop and perform single-cell RNA-seq, single-cell ATAC-seq, single-cell metabolomics and combined omics methodologies using manual and liquid handling platformsExplore in vitro and in vivo models to study human chronic diseases using fresh or archived human samplesShow great attention to detail in experimental design and execution
What we offer
Remuneration and benefits are in accordance with the collective agreement for the public sector (TV EntgO Bund). The positions are initially limited to two years with the option of up to five year extension.
The Helmholtz Zentrum Müchen is an equal opportunity employer and embraces diversity. We are located in one of the most liveable cities in Europe, in a family friendly work environment with a child care facility on Campus and dual career opportunities. Our activities involve special training tailored to your experience and specific career development plans. We are certified as holder of the Total E-Quality Award. In order to increase the proportion of women in management positions, we are pleased to receive corresponding applications. Qualified applicants with physical disabilities will also be given preference.
We are looking forward to receiving your comprehensive online application (motivation letter, CV, contact details of at least 2 referees) in a single pdf until January 15, 2019
Curious? We encourage your inquiries, directly to Dr. Celia P. Martinez-Jimenez at firstname.lastname@example.org