Salary: Grade 7: £32,236 - £39,609 p.a.
Dr Rebecca Burton (Pharmacology) and Professor Manuela Zaccolo (DPAG) seek to recruit a postdoctoral research scientist to join the Cardiac Dynamics and Pacemaking Research group, based in the Department of Pharmacology, in order to study IP3 signalling in the heart. The postholder will utilise calcium signalling, immunocytochemistry, cell culture and electrophysiology methods across a range of spatial scales to investigate the downstream mechanisms by which IP3-mediated calcium release increases atrial contractility.
The Burton Group, established in 2015, carries out multi-disciplinary research into calcium signalling in the cardiac atria with a broad goal to apply our findings into the atrial fibrillation field. We use techniques ranging from conventional electrophysiology to state-of-the-art tissue engineering to study novel, and established, signalling pathways in the heart.
We are seeking someone who is able to manage their own research and administrative activities, be able to adapt existing techniques and experimental protocols, contribute ideas for new research projects that could potentially lead onto the generation of research income. The postholder will manage a colony of transgenic mice and use them, in combination with guinea pig and cultured neonatal rat myocyte studies, to determine the role of calcium-stimulated enzymes in the response to IP3.
The successful applicant must hold a PhD/DPhil in a biomedical subject (or related such as biomedical engineering) and have laboratory experience in cell isolation (Langendorff technique), calcium signalling and/or electrophysiology techniques relevant to the project described and also demonstrate experience in confocal microscopy or related fluorescent imaging methods. Laboratory experience in: tissue culture along with knowledge/experience of conducting siRNA experiments; working with wild-type and genetically-altered mice, enzymatic cell isolation techniques; and iImmunocytochemistry and associated imaging/analysis techniques would be an advantage.
This is a 3-year fixed-term post, funded by the British Heart Foundation.
The closing date for applications is 12.00 noon on Friday 4 January 2019.