Ph.D. candidate (f/m/diverse) in "Computational method development for CRISPR-CAS9 and pharmacogenomics screens"

Helmholtz-Center München - German Research Center for Environmental Health (HMGU) - HMGU - Helmholtz Association

Neuherberg bei München, Bavaria, Germany

Work group:

Institute of Computational Biology

Area of research:

PHD Thesis

Starting date:


Job description:

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

The Institute of Computational Biology is globally recognised for innovations in data analysis and modelling of biological systems and diseases, anchored at the Helmholtz Centre Munich and the Technical University Munich.

For our new junior research group "Systems Biomedicine & Pharmacogenomics" headed by Dr. Michael Menden we are currently looking for a

Ph.D. candidate (f/m/diverse) in "Computational method development for CRISPR-CAS9 and pharmacogenomics screens"

Job Description

The Ph.D. project will focus on studying cancer vulnerabilities, drug resistances and drug target identification with CRISPR-CAS9 screens, and explore pharmacogenetic dependencies to identify target populations with tailored biomarkers of drug response. For this, the student will develop innovative computational methods, explore high-throughput drug and CRISPR-CAS9 screens, derive biomarkers of sensitivity, and ultimately pave the way for personalised medicine.

Aim of the project involves:

Apply and adapt machine learning and biostatistical methods to the genetic landscape of cancer cell lines and CRISPR-CAS9 screens to predict putative drug targets and cancer vulnerabilitiesExploring high-throughput drug screens to develop novel methods for identifying drug sensitivity biomarkerExploiting cancer evolutionary events to build truly innovative methods for personalised medicine

Your Qualifications

Master’s Degree in Bioinformatics, Biostatistics, Physics, Informatics or equivalent with interest in cancer biology, diabetes and early drug development. Alternatively a Master’s Degree in Biotechnology, Biology or equivalent with significant experience and interest in Bioinformatics / BiostatisticsExcellent programming skills in either R, Python or C/C++Scientific curiosity and ability to work independentlyExcited to work in a young and multi-disciplinary, collaborative environment including academic and industrial partnersExcellent communication and presentation skills, including experience in communicating across discipline boundariesFluency in spoken and written English

The following qualifications are considered advantageous:

Working in a Linux environment, with experience of shell scripting, cluster or cloud computingBasic understanding of cancer biology or early drug developmentExperience with the analysis of either CRISPR-CAS9, NGS (transcriptomic and genomic) or pharmacogenomics data (cancer cell line high-throughput screens)Experience in machine learning or multivariate statistics

Our Offer

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.

Remuneration and benefits are in accordance with the collective agreement for the public service (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled.

The position is (initially) limited to three years.

The activity involves special knowledge and experience specific to own scientific skills.

As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.

We are looking forward to receiving your comprehensive online application (Cover letter, CV, certificates, contact details of 2 referees) as a single PDF document until January 15th 2019.

Please apply via recruiter’s website.

Quote Reference: Helmholtz-2018/0564