We are looking for a creative, world class Scientist to join our research team to develop and validate new technology platforms for robust, large-scale synthesis of bio-polymers, such as nucleic acids, for application as therapeutic drugs. The candidate will use cutting edge technologies to overcome process bottlenecks and must be willing to expand their knowledge outside her/his educational field and comfort zone.
The candidate will have 5+ years of research experience in an academic or industry setting, and outstanding scientific and personal skills, including:
• PhD in Biochemistry, Molecular/Cellular biology, Chemical Engineering, or related fields, with excellent bench skills applicable to the chemical/biological synthesis of biopolymers.
• Expertise in molecular biology techniques, including cloning, qPCR, complex library preparation, NGS data analysis and RNA handling knowledge.
• Expertise in mammalian cell culture methods, transfection and setting up cellular assays. Experience with flow cytometry and ELISA would be an advantage.
• Familiarity with HPLC, CE and other QA/QC methods would be an advantage.
The desired candidate must be able to apply her/his knowledge of nucleic acid biochemistry to new challenges, working cross-functionally to drive project timelines and deliverables. He/she must have proven problem-solving skills, highly accurate work product, great attention to detail, excellent written and verbal communication skills and the ability to work independently in a fast-paced work environment.
AREAS OF RESPONSIBILITY
The Senior Biologist will work on both technology platform development as well lead optimization for a number of ongoing therapeutic programs in the company. The selected candidate will report to the VP of biology. The role will include:
Designing experiments to drive the optimization of test vehicles and lead therapeutics, using Design of Experiment principles and statistical data interpretation
Developing and running characterization methods to establish the quality and purity of therapeutic products
Establishing and documenting processes for the repeatable synthesis of GMP-grade materials.
Regularly presenting results at R&D and project meetings and contributing expertise and ideas to cross-functional teams within the company.
Nutcracker Therapeutics is an equal opportunity employer and we value diversity at our company. We do not unlawfully discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.