We are seeking a post doctoral fellow with a strong bioinformatics/computational profile to pursue investigation of atrial fibrillation integrating proteomics and genomics datasets. The post doctoral fellow will collect and analyze high-resolution proteomics data from cardiac biopsies from atrial fibrillation patients followed by data integration with genomics data from the same patient population.
The employment period is for 3 years.
The fellow will become part of the Cardiac Proteomics group led by Associate Professor Alicia Lundby at the Department of Biomedical Sciences and the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen, Denmark. The Cardiac Proteomics group performs high-resolution LC-MS/MS based investigations of the heart to obtain insights beyond the current molecular understanding of the heart; at the level of protein expression as well as phosphorylation mediated protein signaling. We work closely together with cardiologists to ensure a research focus on the most relevant human cardiac biopsies. The project to be undertaken will involve deep quantitative proteome measurements of cardiac biopsies and subsequent data analysis. Importantly, the fellow should work with own collected proteomics datasets as well as genomics datasets collected by collaborators, and integrate the two sets of orthogonal information for studied the patient cohort.
Responsibilities and tasks
The successful candidate will be working in a team of scientists across multiple scientific fields focused on improving our molecular understanding of cardiac pathophysiologies. The candidate will work closely with experimental biologists, bioinformaticians and geneticists to solve fundamental challenges in cardiac research. The position will be ideally suited to a person that has obtained a Ph.D. degree and is interested in pursuing a career in research. The position provides an opportunity to develop expertise in state-of-the-art quantitative mass spectrometry, data analysis of large datasets and integration of matched large-scale datasets. Previous research experience in a competitive environment is a requirement and ideally the candidate has prior experience within cardiac research.
The Post Doctoral position could cover
- Unbiased data-driven analysis of large-scale proteomics datasets of cardiac protein abundances in atrial samples from atrial fibrillation patients
- LC-MS/MS measurements of human cardiac biopsy samples
- Data integration of matched proteomics and genomics datasets
- Exploration of analyses strategies for data integration
The candidate should:
- Hold a Ph.D.
- Ideally have experience in data analysis of genomics data as well as in proteomics data
- Have the ability and the enthusiasm to obtain in-depth understanding of proteomics and genomics data analyses
- Have good communication skills in English, both oral and written
- Be highly ambitious and self-driven
- Have a proven record of bioinformatics and analysis of large-scale datasets
Overall a preferred applicant has an excellent academic track record, solid research experience and is highly motivated to deploy bioinformatics analyses to extract novel findings of importance to cardiac (patho)physiology.
The candidate should
- Have a proven track record within data analysis of proteomics and/or genomics data
- Have demonstrated early in his/her career a capacity for excellence
- Make this position his/her number one priority
- Have a genuine interest in science
- Have a strong work ethics
- Be a team player
We offer an interesting and challenging job in an international environment focusing on cardiac research. You will become part of a research environment spanning cardiologists, geneticists performing next generation sequencing on cardiac patient samples, experimental groups performing follow-up experiments in model organisms such as zebrafish, mouse and pig as well as molecular biologists. We strive for academic excellence, collegial respect and freedom tempered by responsibility.
Salary and terms of employment
Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.
The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 34,980 per month (level 6 to 8). To the basic salary, a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer.
Workplace is located at The Panum Institute, University of Copenhagen, Denmark.
You can read more about the Cardiac Proteomics Group at www.lundbylab.com
You can read more about the Department of Biomedical Sciences at www.bmi.ku.dk/english
You can read more about the Center for Protein Research at www.cpr.ku.dk
Please submit your online application by clicking “apply now” below/ via advertisment https://employment.ku.dk/faculty/ no later than January 2nd 2019.
The file must include
Applications must be submitted as one PDF file containing all materials to be given consideration. Attach all your materials in English in one PDF file. The application should contain:
- Diploma (an official translation into English)
- List of publications
- Contact details for two referees
Applications and enclosures received after the deadline will not be considered.
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at www.employment.ku.dk
The University of Copenhagen encourages all interested applicants to apply for this position.
General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website
The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
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