PhD candidate 'Blindness Genetics'

PhD candidate 'Blindness Genetics'

Radboud University Nijmegen Medical Centre

Radboud, Netherlands

PhD candidate ‘Blindness Genetics’

Job description
Stargardt disease (STGD1) is a progressive retinal disorder that initially affects central vision, and later can progress to a more severe visual impairment, often leading to complete blindness. STGD1 is caused by bi-allelic mutations in ABCA4, a gene that encodes a retina-specific transport protein. Yet, the exact mechanisms on how ABCA4 gene expression is regulated (i.e. transcriptional activation, pre-mRNA splicing) are not yet known, nor have all the genetic causes underlying STGD1 been completely unraveled. Finally, to date, no treatment is available to stop the progression or improve vision of many individuals with STGD1 worldwide.

A consortium of ten different groups from six different European countries have successfully applied for a Marie Sklodowska Curie Action Initial Training Network, coined StarT. This network allows us to hire fourteen PhD candidates to work on the various aspects of ABCA4 and STGD1 mentioned above. The position in my group will focus on developing novel splice modulation therapies for recurrent ABCA4 mutations underlying STGD1. The PhD candidate will be hosted within the Radboudumc, but, given the nature of the training network, receive a lot of training throughout the different participating institutes. In addition, candidates should perform a minimum of two secondments (weeks-to-months) within different partners lab, in order to maximize exchange and cooperation between the different groups.

As per ITN ruling, candidates that apply for a position within the Netherlands should not be Dutch, or have lived within the Netherlands for more than one year during the last three years.

Candidates must have completed a MSc degree in Molecular Life Sciences or a related field. They need to have a solid theoretical background in molecular and cell biology, as well as hands-on experience with standard molecular techniques such as PCR, cloning, RT-PCR, and cell culture. Experience with stem cell technology is considered a strong plus.

Candidates should have a strong ambition to succeed in science, be result-oriented, and have strong communication skills (both orally and in writing). They should possess a critical scientific attitude and should be able to work both independently as well as in a team.

The PhD student will be positioned within the “Blindness Genetics” group, led by Prof. Dr. Frans Cremers, that aims to identify and functionally characterize genetic defects for inherited retinal diseases, with a strong focus on genomics and transcriptomics.

The Department of Human Genetics of the Radboudumc in Nijmegen is internationally renowned for its research and diagnostics on a variety of genetic disorders. The Department offers an exciting working environment with enthusiastic people from many parts of the world, providing ample critical mass and a stimulating, collaborative atmosphere for high quality research.

Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Employment conditions

  • We offer a contract for a limited period of 3 years, 36 hours a week.
  • We offer you a salary in scale 10A: max € 41835 gross per year at full employment (incl. vacation bonus and end of year payments).

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be a screening based on the provided CV. Radboud university medical center’s HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Comments and contact information
The anticipated starting date is the 1st of March, 2019.

All additional information about the vacancy can be obtained from Prof. Dr. Frans Cremers, professor Genetics, via +31 (024) 361 37 50 or Use this Email address only for information.

Applications need to be submitted via the Euraxess application form, where candidates can indicate their preference for this, or any of the other 13 positions.

This vacancy is open until filled.

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