Chemist, Pharmaceutical Chemist, Pharmacist, Physicist  Multimodal imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices in experimental animal models.

Chemist, Pharmaceutical Chemist, Pharmacist, Physicist Multimodal imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices in experimental animal models.

National Research Council (CNR) Institute of Clinical Physiology

Pisa, Italy

The European Training Network “MgSafe” is offering in total

15 PhD positions

in the area of magnesium implant imaging

The EU-funded MSCA-ITN ‘MgSafe’ investigates a novel combination of imaging technologies for biodegradable magnesium implants in order to promote patient safety.

The PhD candidates will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and μCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production. This will be done in vivo and with in situ labelling options to deliver non-invasively data on different time and length scales. The body reaction and material behaviour will be investigated during Mg degradation with a precision and plethora of details, which is currently not available.

We are looking for highly motivated candidates for the following PhD projects (please find more detailes on the website www.mgsafe.eu ):

P6: Chemist, Pharmaceutical Chemist, Pharmacist, Physicist
Multimodal imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices in experimental animal models.

Project description:
The research topic is multimodal imaging of bone regeneration and bone remodelling after implantation of a degradable Mg-based device in experimental animal models. The specific objectives will be: (1) Study of the dynamic regulation of bone regeneration and remodelling. (2) Validation of the probes/target combination, both in vitro and in vivo, following a multimodal approach by small animal Positron Emission Tomography (PET), High frequency Ultrasound (HF-US), and photoacoustic imaging (PAI). (3) Integration of bone metabolism and homeostasis by morphometric measurements. (4) Development of new preclinical imaging strategies for translation in a clinical setting.

Specific Requirements:
The applicant holds a master’s degree in chemistry, pharmaceutical chemistry, pharmacy, or physics and is interested in multi/ interdisciplinary research. Experience with tracer chemistry and physics is required.

P7: Biological or Pharmaceutical Chemist, Biologist, Pharmacist, Medical Scientist
Biochemical and biohumoral studies of bone regeneration and remodelling after implantation.

Project description:
The research topic is to assess circulating biomarkers in order to predict and/or monitor efficacy/toxicity of the degradable implant through a multi-marker technology. This will lead to the development of an integrated approach for biomarker development in the field of Mg-implants. This approach shall be integrated with multimodal and molecular imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices. The specific goals will be: (1) in vitro validation studies with specific probes labelling integrin αvβ3 to detect angiogenesis in vivo; (2) validation of the probes/target combination with state-of-art technologies, both in vitro and in vivo, following a multimodal approach by small animal Positron Emission Tomography (PET), high resolution ultrasound (HR-US) and photoacoustic imaging (PAI), (3) integration of biohumoral and biochemical information with image-derived parameters of bone metabolism.

Specific Requirements:
The applicant holds a master’s degree in biological chemistry, biology, pharmaceutical chemistry, pharmacy, or medicine and is interested in multi/ interdisciplinary research. Experiences in the fields of (bone) tissue remodelling and inflammation biomarkers are advantageous.

Place of work:

National Research Council (CNR) Institute of Clinical Physiology, Pisa, Italy (Prof. L. Menichetti)
National Research Council (CNR) Institute of Clinical Physiology

Our offer:

  • Excellent job opportunities in attractive and well-equipped research groups (e.g. nano and μCT, MRT, PET, USPA, IR, microscopy, cell culture and corrosion laboratories)
  • Intense exchange with researchers located in eight European countries
  • Comprehensive academic support program including subject-specific courses, soft skill training, research stays abroad, individual career coaching
  • 3-year employment contract, salaries according to the EU MSCA-ITN regulations

Your general qualifications:

  • Research-based master’s degree or equivalent (e.g. diploma) in a subject related to the respective position
  • Excellent command of English
  • Pro-active attitude, good communication skills and ability to work effectively in an interdisciplinary international team
  • Flexible, creative, self-organised and able to work independently on multiple tasks
  • Experience in publishing
  • Motivation to participate in the projects training program

Mobility requirements of MSCA-ITN European Training Networks:

Applicants need to be Early-Stage Researchers. They must, at the date of recruitment, be in the first four years (full-time equivalent research experience) of their research careers (= after acquiring MSc degree or similar) and have not been awarded a doctoral degree yet.

Researchers can be of any nationality. They are required to undertake physical, transnational mobility (i.e. move from one country to another) when taking up their appointment. Mobility rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date.

Starting from April 1st 2019, the positions will be awarded for three years.

How to apply:

Please send your application in English indicating job offer code no. 2018/WB 5-P6 or 2018/WB 5-P7 by email preferably in one pdf file not exceeding 10 MB to application.mgsafe@hzg.de. Please DO NOT send applications via email to individual PIs or organisations. Such emails will not be considered.

Make sure that your application includes:

  • a CV which gives an overview of the academic/education history, including a list of courses/exams and grades, the exact award date (day/month/year) of the degree with original transcripts of Bachelor and Master University Degree (or similar) as well as copy of valid identity documents,
  • a list of your publications,
  • a list of skills you acquired during the courses attended at university,
  • a documentation of special skills suitable for the position you apply for,
  • a documentation of your excellent English skills (e.g. TOEFL, IELTS, CAE or CPE with minimum scores of: TOEFL: 600 (paper-based test), 92 (Internet-based test), IELTS: 6.5 with no section lower than 5.5, or equivalent),
  • a copy or half-page summary of master/diploma thesis and
  • a letter of motivation (up to 2 pages) which states your research experience and interests and a concrete project plan, which explains how you envisage your work in the project,
  • names and contact information of at least two academic referees who could write a letter of recommendation.

Deadline for applications: 15.12.2018

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Chemist, Pharmaceutical Chemist, Pharmacist, Physicist Multimodal imaging of bone regeneration and remodelling after implantation of degradable Mg-based devices in experimental animal models.