Physicist, Computer Scientist, Mathematician Structural characterisation of explants by synchrotron radiation: differential phase contrast (DPC) µ and nano tomography for investigation of Mg implant tissue interface.

Physicist, Computer Scientist, Mathematician Structural characterisation of explants by synchrotron radiation: differential phase contrast (DPC) µ and nano tomography for investigation of Mg implant tissue interface.

Deutsches Elektronen-Synchrotron DESY.

Hamburg, Germany

The European Training Network “MgSafe” is offering in total

15 PhD positions

in the area of magnesium implant imaging

The EU-funded MSCA-ITN ‘MgSafe’ investigates a novel combination of imaging technologies for biodegradable magnesium implants in order to promote patient safety.

The PhD candidates will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and μCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production. This will be done in vivo and with in situ labelling options to deliver non-invasively data on different time and length scales. The body reaction and material behaviour will be investigated during Mg degradation with a precision and plethora of details, which is currently not available.

We are looking for highly motivated candidates for the following PhD projects (please find more detailes on the website www.mgsafe.eu ):

P10: Physicist, Computer Scientist, Mathematician
Structural characterisation of explants by synchrotron radiation: differential phase contrast (DPC) µ and nano tomography for investigation of Mg implant tissue interface.

Project description:
The research topic is imaging and characterisation of Mg implants in native tissue environments. This will be investigated by applying high‐energy differential phase contrast (DPC) tomographic imaging, and create multimodal image data sets integrating phase, attenuation and dark field CT‐data. The project will focus on the optimisation of SR tomography contrast techniques and data analysis protocols for the characterisation of metallic implant tissue interfaces and the implementation of approaches for multimodal data analysis e.g. including Deep / Machine Learning approaches.

Specific Requirements:
The applicant holds a master’s or diploma degree in physics, or related areas. Experience in the field of x-ray imaging and image processing, including processing/scripting skills to develop custom data analysis pipelines, is required. Expertise in instrumentation and setup development is highly appreciated.

P11: Physicist, Mathematician, Computer Scientist
Structural characterisation of explants by synchrotron radiation: Bone remodelling at the implant-bone interface, SAXS investigations.

Project description:
The aim of the research topic is the investigation of the bone implant interface by use of high‐resolution x-ray scattering. The applicant will perform diffraction and small angle x‐ray scattering experiments with x-ray beams of the size of 250 nm to elucidate differences in bone structure close to the implant interface and in distant bone and to investigate if corrosion products (e.g. hydroxyapatite) are ordered in a bone like fashion. This is complemented by histological and spectroscopic techniques to correlate structure and function of degradable implants.

Specific Requirements:
The applicant holds a master’s degree in physics, mathematics, or related areas. Experience in x-ray scattering, ideally x-ray diffraction or small angle scattering, and/or programming is required. Knowledge in the field of machine learning would be beneficial.

Place of work:

HZG- outstation at DESY, Hamburg, of the Helmholtz-Zentrum Geesthacht, Institute for Materials Research, Germany (Prof. R. Willumeit-Römer)
Helmholtz-Zentrum Geesthacht, Metallic Biomaterials

Our offer:

  • Excellent job opportunities in attractive and well-equipped research groups (e.g. nano and μCT, MRT, PET, USPA, IR, microscopy, cell culture and corrosion laboratories)
  • Intense exchange with researchers located in eight European countries
  • Comprehensive academic support program including subject-specific courses, soft skill training, research stays abroad, individual career coaching
  • 3-year employment contract, salaries according to the EU MSCA-ITN regulations

Your general qualifications:

  • Research-based master’s degree or equivalent (e.g. diploma) in a subject related to the respective position
  • Excellent command of English
  • Pro-active attitude, good communication skills and ability to work effectively in an interdisciplinary international team
  • Flexible, creative, self-organised and able to work independently on multiple tasks
  • Experience in publishing
  • Motivation to participate in the projects training program

Mobility requirements of MSCA-ITN European Training Networks:

Applicants need to be Early-Stage Researchers. They must, at the date of recruitment, be in the first four years (full-time equivalent research experience) of their research careers (= after acquiring MSc degree or similar) and have not been awarded a doctoral degree yet.

Researchers can be of any nationality. They are required to undertake physical, transnational mobility (i.e. move from one country to another) when taking up their appointment. Mobility rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the recruiting beneficiary for more than 12 months in the 3 years immediately before the recruitment date.

Starting from April 1st 2019, the positions will be awarded for three years.

How to apply:

Please send your application in English indicating job offer code no. 2018/WB 5-P10 or 2018/WB 5-P11 by email preferably in one pdf file not exceeding 10 MB to application.mgsafe@hzg.de. Please DO NOT send applications via email to individual PIs or organisations. Such emails will not be considered.

Make sure that your application includes:

  • a CV which gives an overview of the academic/education history, including a list of courses/exams and grades, the exact award date (day/month/year) of the degree with original transcripts of Bachelor and Master University Degree (or similar) as well as copy of valid identity documents,
  • a list of your publications,
  • a list of skills you acquired during the courses attended at university,
  • a documentation of special skills suitable for the position you apply for,
  • a documentation of your excellent English skills (e.g. TOEFL, IELTS, CAE or CPE with minimum scores of: TOEFL: 600 (paper-based test), 92 (Internet-based test), IELTS: 6.5 with no section lower than 5.5, or equivalent),
  • a copy or half-page summary of master/diploma thesis and
  • a letter of motivation (up to 2 pages) which states your research experience and interests and a concrete project plan, which explains how you envisage your work in the project,
  • names and contact information of at least two academic referees who could write a letter of recommendation.

Deadline for applications: 15.12.2018

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Physicist, Computer Scientist, Mathematician Structural characterisation of explants by synchrotron radiation: differential phase contrast (DPC) µ and nano tomography for investigation of Mg implant tissue interface.