The Lawrence J. Ellison Institute for Transformative Medicine of USC is a multidisciplinary research institute developing innovative approaches in the prevention and treatment of cancer in order to significantly impact patients’ health and quality of life. We focus on understanding complex tumor-microenvironmental interactions and discovering optimal approaches for personalizing patient care. Our vision is to use a patient’s own metrics (genetic information, molecular tumor markers, dynamic tumor cell behaviors and drug responses across diverse microenvironments) to determine the most effective treatment. We are currently investigating a broad range of biological systems, including cell culture, mouse models, and patient-derived tissues.
We are seeking a talented and passionate research lab specialist who has a strong interest in cancer biology. The qualified candidate will work on projects studying the impact that exosomes derived from the tumor microenvironment have on pancreatic cancer initiation, progression, and therapeutic resistance using 2D and 3D cell cultures and in vivo mouse models. The projects will involve isolating extracellular vesicles produced by cancer associated fibroblasts, and pancreatic cancer cells; characterizing the cargo of the isolated microvesicles; and examining if the isolated microvesicles are able to induce phenotypic and genotypic changes on neighboring healthy and diseased cells.
Experimental duties include, but are not limited to: mouse husbandry, PCR-based genotyping, in vivo drug treatments, mouse dissection, preparation and analysis of tissue samples, isolation of DNA/RNA/protein, immunoblot, cell culture and cell assays, and statistical analyses. The position also needs basic lab maintenance, including preparation of buffers, gels and medium, reagent ordering and organization. The ability to accurately and efficiently manage multiple lab tasks is required. The candidate will work in close collaboration with a diverse team consisting of cancer researchers, computational scientists and clinicians.
Candidates should have a B.S./M.S. degree in molecular/cellular biology, biochemistry, or other relevant discipline. Applicants must have training in mammalian tissue culture (2D and 3D) and experience with mouse tumor models (e.g., subcutaneous implantation, drug dosing, measuring tumors and tumor harvest.
Excellent verbal and communication skills, and the ability to work in a team environment are required. Key success factors in the performance of this position include attention to detail, the ability to collaborate across disciplines, and curiosity.
Interested individuals should provide their CV and a 1-2 page cover letter describing their professional goals and how their research experience can advance these research goals.
Preferred Education: B.S. or M.S. degree in molecular/cellular biology, biochemistry, or other relevant discipline
Preferred Experience: Minimum of 3 years laboratory experience
Preferred Field of Expertise: Applicants must have training in mammalian tissue culture (2D and 3D) and experience with mouse tumor models (e.g., subcutaneous implantation, drug dosing, measuring tumors and tumor harvest).
Posting Salary Range: $45,180 – 75,298