Job title: Postdoctoral Training Fellow
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 4 years
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 9185
This position is for a Postdoctoral Training Fellow in the Cell Biology of Infection Laboratory led by Rupert Beale. The post holder will use a wide variety of methods to understand the interactions between viruses and the host autophagy machinery. Candidates should have a PhD or equivalent, and a strong background in molecular and cell biology.
We have discovered that influenza infection triggers an intracellular pathway that is related to autophagy but has a distinct molecular basis. Influenza M2 proton channel activity triggers a collapse in intracellular pH gradients. This causes lipidation of the key autophagy protein LC3. We aim to define the pathways triggered by influenza M2, and discover their biological purposes. We are currently engaged in defining the components using CRISPR screens. In parallel, we aim to define the compartments targeted by LC3 during infection with influenza using advanced microscopy and proteomic techniques. We will go on to define autophagy-related pathways triggered by a variety of pathogens.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 1st of January.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.