The aim of the project is to study the innate and adaptive immune cell crosstalk in cardiac injury responses, in particular within pericardial fat-associated lymphoid clusters. The project involves the following techniques: (i) Mouse models of myocardial infarction and pressure overload-induced cardiac remodeling; (ii) Flow cytometry, advanced imaging methods (e.g. TPLSM, STED); (iii) Single cell RNA sequencing.
Your profile: Eligible candidates should have experience with (cardiovascular) mouse models, immunological and bioimaging techniques. Experience with transcriptomic data analysis would be an additional advantage. You should have a strong motivation and team spirit as well as the curiosity, enthusiasm and driving force to bring a scientific question to the utmost end. German language skills are a plus, but not essential. However, solid English skills written and spoken are mandatory. We offer a stimulating international research environment, excellent equipment and close interaction to benefit from the broad expertise of the various groups in our institute (http://ipek.klinikum.uni-muenchen.de). The project is funded by the German Centre for Cardiovascular Research (DZHK) and associated to the SFB (Collaborative Research Center 1123) “Atherosclerosis – Mechanisms and Networks of Novel Therapeutic Targets”. For more information, please visit the websites https://dzhk.de/ and http://www.sfb1123.med.uni-muenchen.de/index.html.
Relevant publications: Horckmans et al. and Steffens S (2017). European Heart Journal, 38(3):187-197; Horckmans et al. and Steffens S (2018). Circulation 137(9):948-960; Schloss et al. and Steffens S (2018). Cardiovasc Res. 2018 Sep 28.
Interested candidates should submit their application (including CV, publication list and references) via email (single merged PDF) to Dr. Sabine Steffens.